This Article  • Full text  • PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Citing articles on Web of Science (46)  • Contact me when this article is cited  Related Content  • Related article  • Similar articles in this journal  Topic Collections  • Neurology  • Neuro-ophthalmology  • Glaucoma  • Alert me on articles by topic  Social Bookmarking   What's this?

Martin B. Wax, MD; Gülgün Tezel, MD; P. Deepak Edward, MD

Arch Ophthalmol. 1998;116:993-1001.

Objective  To study the histopathological changes of eyes from a patient with normal-pressure glaucoma whose clinical and laboratory findings were well documented.

Methods  Postmortem histopathological findings in a patient with normal-pressure glaucoma who had monoclonal gammopathy and serum immunoreactivity to retinal proteins were examined in comparison with those of an age-matched control subject. Clinicopathological correlations to laboratory findings were examined.

Results  Clinical and histopathological findings of the patient, including cavernous degeneration of optic nerve and characteristic optic nerve cupping, were similar to those in patients with glaucoma who had high intraocular pressure. In addition, we found immunoglobulin G and immonuglobulin A deposition in the ganglion cells, inner and outer nuclear layers of the retina, and evidence of apoptotic retinal cell death using terminal deoxynucleotidyltransferase-mediated deoxyuridine triphosphate nick end labeling technique.

Conclusions  Serum antibodies to retinal proteins and retinal immunoglobulin deposition constitute novel findings in a patient with normal-pressure glaucoma and may contribute to better understanding of the mechanisms underlying glaucomatous optic neuropathy in this disorder.

From the Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, Mo (Drs Wax and Tezel), and the University of Illinois, Chicago (Dr Edward). The authors have no proprietary interest in any of the materials used in this study.

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

RELATED ARTICLE

Toward Understanding the Optic Neuropathy of Glaucoma
Robert N. Weinreb
Arch Ophthalmol. 1998;116(8):1102-1103.
EXTRACT | FULL TEXT  

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

The Role of Glia, Mitochondria, and the Immune System in Glaucoma
Tezel and the Fourth ARVO/Pfizer Ophthalmics Research Instit
IOVS 2009;50:1001-1012.
FULL TEXT  

Induced Autoimmunity to Heat Shock Proteins Elicits Glaucomatous Loss of Retinal Ganglion Cell Neurons via Activated T-Cell-Derived Fas-Ligand
Wax et al.
J. Neurosci. 2008;28:12085-12096.
ABSTRACT | FULL TEXT  

Mechanisms of Immune System Activation in Glaucoma: Oxidative Stress-Stimulated Antigen Presentation by the Retina and Optic Nerve Head Glia
Tezel et al.
IOVS 2007;48:705-714.
ABSTRACT | FULL TEXT  

Transcriptional Up-Regulation and Activation of Initiating Caspases in Experimental Glaucoma
Huang et al.
Am. J. Pathol. 2005;167:673-681.
ABSTRACT | FULL TEXT  

Calcineurin cleavage is triggered by elevated intraocular pressure, and calcineurin inhibition blocks retinal ganglion cell death in experimental glaucoma
Huang et al.
Proc. Natl. Acad. Sci. USA 2005;102:12242-12247.
ABSTRACT | FULL TEXT  

Hypoxia-Inducible Factor 1{alpha} in the Glaucomatous Retina and Optic Nerve Head
Tezel and Wax
Arch Ophthalmol 2004;122:1348-1356.
ABSTRACT | FULL TEXT  

Vitreal Glutamate Concentration in Monkeys with Experimental Glaucoma
Carter-Dawson et al.
IOVS 2002;43:2633-2637.
ABSTRACT | FULL TEXT  

TNF-{{alpha}} and TNF-{{alpha}} Receptor-1 in the Retina of Normal and Glaucomatous Eyes
Tezel et al.
IOVS 2001;42:1787-1794.
ABSTRACT | FULL TEXT  

Clinical Factors Associated With Progression of Glaucomatous Optic Disc Damage in Treated Patients
Tezel et al.
Arch Ophthalmol 2001;119:813-818.
ABSTRACT | FULL TEXT  

Serum Autoantibody against Glutathione S-Transferase in Patients with Glaucoma
Yang et al.
IOVS 2001;42:1273-1276.
ABSTRACT | FULL TEXT  

Induction of HLA-DR Expression in Human Lamina Cribrosa Astrocytes by Cytokines and Simulated Ischemia
Yang et al.
IOVS 2001;42:365-371.
ABSTRACT | FULL TEXT  

The Mechanisms of hsp27 Antibody-Mediated Apoptosis in Retinal Neuronal Cells
Tezel and Wax
J. Neurosci. 2000;20:3552-3562.
ABSTRACT | FULL TEXT  

Matrix Metalloproteinases and Tumor Necrosis Factor {alpha} in Glaucomatous Optic Nerve Head
Yan et al.
Arch Ophthalmol 2000;118:666-673.
ABSTRACT | FULL TEXT  

Nitric Oxide Mediates Excitotoxic and Anoxic Damage in Rat Retinal Ganglion Cells Cocultured With Astroglia
Morgan et al.
Arch Ophthalmol 1999;117:1524-1529.
ABSTRACT | FULL TEXT  

Inhibition of Caspase Activity in Retinal Cell Apoptosis Induced by Various Stimuli In Vitro
Tezel and Wax
IOVS 1999;40:2660-2667.
ABSTRACT | FULL TEXT  

Serum Autoantibodies to Optic Nerve Head Glycosaminoglycans in Patients With Glaucoma
Tezel et al.
Arch Ophthalmol 1999;117:917-924.
ABSTRACT | FULL TEXT  

New Perspectives on Glaucoma
Dreyer and Lipton
JAMA 1999;281:306-308.
FULL TEXT  

Toward Understanding the Optic Neuropathy of Glaucoma
Weinreb
Arch Ophthalmol 1998;116:1102-1103.
FULL TEXT