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Justin L. Gottlieb, MD; Jeffrey P. Blice, MD; Bernadette Mestichelli, BS, MT(ASCP); Barbara A. Konkle, MD; William E. Benson, MD

Arch Ophthalmol. 1998;116:577-579.

Objective  To confirm the relationship between resistance to activated protein C (APC), factor V Leiden, and central retinal vein occlusion in young adults as reported in a recent study of patients younger than 50 years.

Patients and Methods  Patients younger than 50 years with central retinal vein occlusion were identified from the medical records of the Wills Eye Hospital Retina and Retina Vascular Services. Blood samples were taken from each patient and analyzed for resistance to APC and identification of factor V Leiden.

Results  Only 1 (4.7%) of 21 patients evidenced resistance to APC and the presence of factor V Leiden. This patient was also the only one to report a family history of thrombotic disease.

Conclusions  We were unable to confirm the high percentage of resistance to ACP among young adult patients with central retinal vein occlusion. The finding of resistance to APC in only 1 (4.7%) of 21 patients is similar to that found in the general population.

From the Retina Service of Wills Eye Hospital (Drs Gottlieb, Blice, and Benson) and the Cardeza Foundation for Hematologic Research, Department of Medicine, Thomas Jefferson University (Ms Mestichelli and Dr Konkle), Philadelphia, Pa. Dr Gottlieb is now with the Department of Ophthalmology and Visual Science, University of Wisconsin, Madison.

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