 |
|
Relationship of Optic Disc Topography to Optic Nerve Fiber Number in Glaucoma
Yeni H. Yücel, MD, PhD;
Neeru Gupta, MD, PhD;
Michael W. Kalichman, PhD;
Andrew P. Mizisin, PhD;
William Hare, PhD;
Marcia de Souza Lima, MD;
Linda Zangwill, PhD;
Robert N. Weinreb, MD
Arch Ophthalmol. 1998;116:493-497.
Objective To assess the relationship between in vivo measurements of optic disc topography and histomorphometric measurements of optic nerve fiber number in glaucoma.
Methods Both eyes of 10 monkeys (Macaca fascicularis) with laser-induced glaucoma in the right eye were studied. Optic disc topography was measured in vivo with a confocal scanning laser ophthalmoscope. Histomorphometry was performed on optic nerve cross sections using bright-field microscopy with camera lucida. Nerve fiber density was estimated by unbiased random sampling. Nerve fiber number was estimated for each sector by multiplying nerve fiber density with neuroglial area. Nerve fiber count was compared with each of 13 global optic disc topographic parameters.
Results For neuroretinal measurements in the glaucomatous eyes, rim area, retinal nerve fiber layer (RNFL) cross-sectional area, rim volume, and RNFL thickness correlated significantly with optic nerve fiber number. Differences in nerve fiber count between control and glaucomatous optic nerves showed the strongest correlation with differences in mean height contour; this was followed by RNFL cross-sectional area, RNFL thickness, rim volume, and differences in rim area. For cup measurements in the glaucomatous eyes, cup volume below reference, cup area, mean cup depth, the ratio of cup area to disc area, and cup shape correlated significantly with nerve fiber number. Differences in nerve fiber number between control and glaucomatous optic nerves showed the strongest correlation with differences in cup shape; this was followed by mean cup depth, cup volume below reference, the ratio of cup area to disc area, cup area, and differences in cup volume below surface. No association was found between optic nerve fiber number and optic disc area in glaucomatous eyes.
Conclusions In experimental glaucoma, most optic disc topography measures correlated significantly with optic nerve fiber number. The results of this histomorphometric study support the use of confocal scanning laser ophthalmoscopy to evaluate optic nerve damage in glaucoma.
From the Glaucoma Center (Drs Yücel, Gupta, de Souza Lima, Zangwill, and Weinreb) and the Department of Pathology (Drs Kalichman and Mizisin), University of California, San Diego; the Department of Ophthalmology, University of Toronto, Ontario (Dr Gupta); and the Department of Biological Sciences, Allergan Inc, Irvine, Calif (Dr Hare). Dr Yücel is now with the Department of Ophthalmology, University of Toronto. The authors have no proprietary interest in the Heidelberg Retina Tomograph.
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati  Twitter
What's this?
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
|
Relationship of Retinal Vascular Caliber with Retinal Nerve Fiber Layer Thickness: The Singapore Malay Eye Study
Zheng et al.
IOVS 2009;50:4091-4096.
ABSTRACT
| FULL TEXT
Optical coherence tomography is less sensitive than visual evoked potentials in optic neuritis
Naismith et al.
Neurology 2009;73:46-52.
ABSTRACT
| FULL TEXT
Optical coherence tomography differs in neuromyelitis optica compared with multiple sclerosis
Naismith et al.
Neurology 2009;72:1077-1082.
ABSTRACT
| FULL TEXT
Retinotopic Organization of Primary Visual Cortex in Glaucoma: A Method for Comparing Cortical Function with Damage to the Optic Disk
Duncan et al.
IOVS 2007;48:733-744.
ABSTRACT
| FULL TEXT
A statistical approach to the evaluation of covariate effects on the receiver operating characteristic curves of diagnostic tests in glaucoma.
Medeiros et al.
IOVS 2006;47:2520-2527.
ABSTRACT
| FULL TEXT
Memantine protects neurons from shrinkage in the lateral geniculate nucleus in experimental glaucoma.
Yucel et al.
Arch Ophthalmol 2006;124:217-225.
ABSTRACT
| FULL TEXT
Optic disc topographic parameters measured in the normal cynomolgus monkey by confocal scanning laser tomography
Taniguchi et al.
Br J Ophthalmol 2005;89:1058-1062.
ABSTRACT
| FULL TEXT
Heidelberg Retina Tomograph Measurements of the Optic Disc and Parapapillary Retina for Detecting Glaucoma Analyzed by Machine Learning Classifiers
Zangwill et al.
IOVS 2004;45:3144-3151.
ABSTRACT
| FULL TEXT
Efficacy and Safety of Memantine Treatment for Reduction of Changes Associated with Experimental Glaucoma in Monkey, II: Structural Measures
Hare et al.
IOVS 2004;45:2640-2651.
ABSTRACT
| FULL TEXT
Quantifying Retinal Nerve Fiber Layer Thickness Histologically: A Novel Approach to Sectioning of the Retina
Blumenthal
IOVS 2004;45:1404-1409.
ABSTRACT
| FULL TEXT
Blood flow per unit retinal nerve fibre tissue volume is lower in the human inferior retina
Harris et al.
Br J Ophthalmol 2003;87:184-188.
ABSTRACT
| FULL TEXT
Comparing Neural Networks and Linear Discriminant Functions for Glaucoma Detection Using Confocal Scanning Laser Ophthalmoscopy of the Optic Disc
Bowd et al.
IOVS 2002;43:3444-3454.
ABSTRACT
| FULL TEXT
Relationship between Electrophysiological, Psychophysical, and Anatomical Measurements in Glaucoma
Garway-Heath et al.
IOVS 2002;43:2213-2220.
ABSTRACT
| FULL TEXT
Scaling the Hill of Vision: The Physiological Relationship between Light Sensitivity and Ganglion Cell Numbers
Garway–Heath et al.
IOVS 2000;41:1774-1782.
ABSTRACT
| FULL TEXT
Relation of optic disc topography and age to thickness of retinal nerve fibre layer as measured using scanning laser polarimetry, in normal subjects
Toprak and Yilmaz
Br J Ophthalmol 2000;84:473-478.
ABSTRACT
| FULL TEXT
Loss of Neurons in Magnocellular and Parvocellular Layers of the Lateral Geniculate Nucleus in Glaucoma
Yucel et al.
Arch Ophthalmol 2000;118:378-384.
ABSTRACT
| FULL TEXT
Assessment of Optic Disc Topography for Diagnosing and Monitoring Glaucoma
Weinreb
Arch Ophthalmol 1998;116:1229-1231.
FULL TEXT
|
