 |
|
Interferon-Induced Protein 10 and Interleukin 8
C-X-C Chemokines Present in Proliferative Diabetic Retinopathy
Susan G. Elner, MD;
Robert Strieter, MD;
Zong Mei Bian, MD;
Steven Kunkel, PhD;
Leila Mokhtarzaden, BS;
Mark Johnson, MD;
Nicholas Lukacs, PhD;
Victor M. Elner, MD, PhD
Arch Ophthalmol. 1998;116:1597-1601.
Objective To determine vitreous levels of interleukin 8 (IL-8) and interferon-induced protein 10 (IP-10), which are members of the C-X-C chemokine family that promote and inhibit neovascularization, respectively.
Methods We measured the levels of IL-8 and IP-10 by specific enzyme-linked immunosorbent assays in the vitreous from 30 patients with proliferative diabetic retinopathy (PDR) and 10 control patients undergoing vitrectomy for idiopathic macular holes or idiopathic macular puckers.
Results Detectable levels of IL-8 were found in 23 of 24 patients with active PDR, 4 of 6 patients with inactive PDR, and 6 of 10 controls. Levels of IL-8 were significantly increased in vitreous samples from the patients with active PDR (P=.02) when compared with vitreous samples from the controls. The IL-8 levels detected in vitreous samples from patients with inactive PDR were not significantly elevated over those found in the control samples. Interferon-induced protein 10 was detected in the vitreous samples from 23 of 24 patients with active PDR, all patients with inactive PDR, and 9 of 10 controls. Significant elevations of IP-10 were measured in samples from patients with active PDR (P=.004) and in those with inactive PDR (P=.00) over those from controls. In addition, levels of IP-10 were significantly elevated in vitreous samples from patients with inactive PDR compared with vitreous samples from patients with active PDR (P=.02).
Conclusion Both IL-8 and IP-10 participate in the pathogenesis of PDR.
From the Departments of Ophthalmology (Drs S. G. Elner, Bian, Johnson, and V. M. Elner and Ms Mokhtarzaden), Pathology (Drs Kunkel and Lukacs), and Internal Medicine (Dr Strieter), University of Michigan, Ann Arbor.
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati  Twitter
What's this?
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
|
Strain-Dependent Increases in Retinal Inflammatory Proteins and Photoreceptor FGF-2 Expression in Streptozotocin-Induced Diabetic Rats
Kirwin et al.
IOVS 2009;50:5396-5404.
ABSTRACT
| FULL TEXT
Control of Chemokine Gradients by the Retinal Pigment Epithelium
Shi et al.
IOVS 2008;49:4620-4630.
ABSTRACT
| FULL TEXT
Expression of CXCL8, CXCR1, and CXCR2 in Neurons and Glial Cells of the Human and Rabbit Retina
Goczalik et al.
IOVS 2008;49:4578-4589.
ABSTRACT
| FULL TEXT
Fractalkine, a CX3C Chemokine, as a Mediator of Ocular Angiogenesis
You et al.
IOVS 2007;48:5290-5298.
ABSTRACT
| FULL TEXT
Role of Chemokines in Endocrine Autoimmune Diseases
Rotondi et al.
Endocr. Rev. 2007;28:492-520.
ABSTRACT
| FULL TEXT
Serum Inflammatory Markers in Diabetic Retinopathy
Meleth et al.
IOVS 2005;46:4295-4301.
ABSTRACT
| FULL TEXT
CD4-CD8 and CD28 Expression in T Cells Infiltrating the Vitreous Fluid in Patients With Proliferative Diabetic Retinopathy: A Flow Cytometric Analysis
Canton et al.
Arch Ophthalmol 2004;122:743-749.
ABSTRACT
| FULL TEXT
Vitreous polyamines spermidine, putrescine, and spermine in human proliferative disorders of the retina
Nicoletti et al.
Br J Ophthalmol 2003;87:1038-1042.
ABSTRACT
| FULL TEXT
Role and Expression of CD40 on Human Retinal Pigment Epithelial Cells
Willermain et al.
IOVS 2000;41:3485-3491.
ABSTRACT
| FULL TEXT
Prevention of ischemia-induced retinopathy by the natural ocular antiangiogenic agent pigment epithelium-derived factor
Stellmach et al.
Proc. Natl. Acad. Sci. USA 2001;98:2593-2597.
ABSTRACT
| FULL TEXT
|
