This Article  • Full text  • PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Citing articles on Web of Science (35)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Topic Collections  • Ophthalmology, Other  • Alert me on articles by topic  Social Bookmarking   What's this?

Okihiro Nishi, MD; Kayo Nishi, MD

Arch Ophthalmol. 1998;116:1358-1361.

Objective  To restore accommodation in primate eyes by refilling the lens capsule with injectable silicone compounds.

Materials and Methods  Eight eyes of 8 monkeys (Macaca fascicularis) were treated by the lens refilling procedure. To prevent leakage of the injected liquid silicone before it polymerized in the capsule in vivo, a silicone plug for sealing the capsular opening was developed. After endocapsular phacoemulsification following an upper minicircular capsulorhexis, the plug was introduced into the capsulorhexis opening. A silicone mixture was injected into the capsular bag through the delivery tube of the plug. Automated refractometry was performed 1 week and 3 months after surgery. Accommodation amplitude was determined as the difference between the refractions before and 1 hour after topical application of 4% pilocarpine chloride.

Results  Five of 8 eyes could be refilled. In 4 of 5 eyes, refraction could be measured. Accommodation amplitude ranged from 1.0 to 4.5 diopters, with a mean of 2.3±1.3 diopters (8.0±2.0 preoperative values). At 3-month examination, thick posterior capsule opacification precluded refractometry in all eyes.

Conclusions  The lens refilling procedure with the use of a silicone plug for sealing the capsular opening was feasible in primate eyes. The accommodation amplitude attained was a small fraction of the value before surgery. This may result from the loss of so-called intracapsular accommodation, ie, active participation of lens fiber cells in accommodation. However, since the obtained accommodation may be sufficient for near vision after cataract surgery, this lens refilling procedure warrants further study. Elucidation of the mechanism of intracapsular accommodation may also be necessary.

From the Nishi Eye Hospital, Osaka, Japan.

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Role of the Lens Capsule on the Mechanical Accommodative Response in a Lens Stretcher
Ziebarth et al.
IOVS 2008;49:4490-4496.
ABSTRACT | FULL TEXT  

Changes in Spherical Aberration after Lens Refilling with a Silicone Oil
Wong et al.
IOVS 2007;48:1261-1267.
ABSTRACT | FULL TEXT  

Accommodative lens refilling in rhesus monkeys.
Koopmans et al.
IOVS 2006;47:2976-2984.
ABSTRACT | FULL TEXT  

Potential of the 1 CU accommodative intraocular lens
Sauder et al.
Br J Ophthalmol 2005;89:1289-1292.
ABSTRACT | FULL TEXT  

In vitro and in vivo study of lens refilling with poloxamer hydrogel
Han et al.
Br J Ophthalmol 2003;87:1399-1402.
ABSTRACT | FULL TEXT  

Polymer Refilling of Presbyopic Human Lenses In Vitro Restores the Ability to Undergo Accommodative Changes
Koopmans et al.
IOVS 2003;44:250-257.
ABSTRACT | FULL TEXT