Human photoreceptor transplantation in retinitis pigmentosa. A safety study
H. J. Kaplan, T. H. Tezel, A. S. Berger, M. L. Wolf and L. V. Del Priore
Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, Mo, USA.
OBJECTIVE: To establish the technical feasibility and safety of
photoreceptor transplantation in retinitis pigmentosa. METHODS: A sheet of
human photoreceptor cells was harvested from 2 human cadaveric eyes with a
vibratome and transplanted into the subretinal spaces of 2 patients with
advanced retinitis pigmentosa and visual acuity of no light perception by
means of submacular surgery techniques. Preoperative and postoperative
electrophysiologic testing, fundus photography, fluorescein angiography,
and scanning laser ophthalmoscopy were performed. RESULTS: Twelve months
after photoreceptor transplantation, the visual acuity of each patient
remained no light perception. The temporal edge of the retinotomy in 1
patient was folded but was not associated with a retinal detachment. The
patients were not immunosuppressed, and there was no evidence of rejection
of the allogeneic transplant. Cystoid macular edema, uveitis, and macular
pucker were not observed. CONCLUSION: A sheet of adult human photoreceptor
cells can be harvested from human cadaveric eyes and safely transplanted to
the subretinal spaces of patients with retinitis pigmentosa without
systemic immunosuppression.
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