Laser treatment in subjects with high-risk clinical features of age-related macular degeneration. Posterior pole appearance and retinal function
R. H. Guymer, M. Gross-Jendroska, S. L. Owens, A. C. Bird and F. W. Fitzke
Department of Clinical Ophthalmology, Eye Hospital, London, England.
OBJECTIVES: To verify that a few laser lesions in the posterior pole can
cause drusen to resolve in patients with age-related macular degeneration,
and to document central retinal sensitivity as drusen resolve. DESIGN: In a
pilot study, 12 patients considered to be at high risk for
sight-threatening complications from age-related macular degeneration were
treated with 12 argon laser lesions in the posterior pole, with review for
12 to 24 months. RESULTS: Choroidal neovascularization developed in 1
patient 8 months after treatment, with consequent loss of central vision.
In 9 of the remaining 11 patients, high-risk characteristics of drusen were
reduced. Four patients had retinal pigment epithelial depigmentation, and
all maintained 20/40 visual acuity at 12 months. One patient lost 3 lines
of vision due to geographic atrophy after 12 months. Scotopic retinal
threshold was elevated before treatment in 8 patients, compared with an
age-matched comparison group. Of these, 4 patients underwent retesting 3 to
6 months after treatment, and all had improved thresholds, but only 1
patient sustained the improvement at 12 months. At 12 months, 3 of the 8
patients showed an improvement in their mean retinal threshold. Of those in
whom the mean retinal threshold worsened, the mean elevation in threshold
was not more than 0.6 log units. CONCLUSIONS: A few laser lesions in the
posterior pole leads to resolution of drusen. There does not appear to be
an increased risk for choroidal neovascularization. Retinal threshold
measurements show no indication of geographic atrophy at 1 year, but cannot
be excluded as a late outcome. Laser treatment may reduce the risk for
profound sight-threatening lesions in age-related macular degeneration.
Correlation of Functional Impairment and Morphological Alterations in Patients With Group 2A Idiopathic Juxtafoveal Retinal Telangiectasia
Schmitz-Valckenberg et al.
Arch Ophthalmol 2008;126:330-335.
ABSTRACT
| FULL TEXT
Maculopathy Due to the R345W Substitution in Fibulin-3: Distinct Clinical Features, Disease Variability, and Extent of Retinal Dysfunction.
Michaelides et al.
IOVS 2006;47:3085-3097.
ABSTRACT
| FULL TEXT
Further validation of the Daily Living Tasks Dependent on Vision: identification of domains
Hart et al.
Br. J. Ophthalmol. 2005;89:1127-1130.
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Spare the rod and spoil the eye
Arden et al.
Br. J. Ophthalmol. 2005;89:764-769.
ABSTRACT
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Comparison of Fundus Autofluorescence with Photopic and Scotopic Fine-Matrix Mapping in Patients with Retinitis Pigmentosa and Normal Visual Acuity
Robson et al.
IOVS 2004;45:4119-4125.
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Photopic and Scotopic Fine Matrix Mapping of Retinal Areas of Increased Fundus Autofluorescence in Patients with Age-Related Maculopathy
Scholl et al.
IOVS 2004;45:574-583.
ABSTRACT
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Expression of Metalloproteinases from Human Retinal Pigment Epithelial Cells and Their Effects on the Hydraulic Conductivity of Bruch's Membrane
Ahir et al.
IOVS 2002;43:458-465.
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Influence of laser photocoagulation on choroidal capillary cytoarchitecture
Guymer et al.
Br. J. Ophthalmol. 2001;85:40-46.
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Psychophysical Evidence for Rod Vulnerability in Age-Related Macular Degeneration
Owsley et al.
IOVS 2000;41:267-273.
ABSTRACT
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Tissue Effects of Subclinical Diode Laser Treatment of the Retina
Pollack et al.
Arch Ophthalmol 1998;116:1633-1639.
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Alternative therapies in exudative age related macular degeneration
CHONG and BIRD
Br. J. Ophthalmol. 1998;82:1441-1443.
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Prophylactic laser treatment in early age related maculopathy reduced the incidence of exudative complications
Frennesson and Nilsson
Br. J. Ophthalmol. 1998;82:1169-1174.
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