 |
|
Immunologic Mechanisms of UveitisNew Targets for Immunomodulation
Scott M. Whitcup, MD;
Robert B. Nussenblatt, MD
Arch Ophthalmol. 1997;115(4):520-525.
Abstract
The uvea consists of the choroid, ciliary body, and iris, and inflammation of the uveal tract is termed uveitis. Nevertheless, uveitis is commonly used to more generally describe intraocular inflammation involving not only the uvea, but also the retina, vitreous, and sclera. Fifty years ago, infectious organisms such as syphilis and tuberculosis were thought to be the cause of most forms of uveitis.1 Since that time, many causes of uveitis have been described as infectious and noninfectious. Scientists have shown that the immune response plays a critical role in the development of infectious and noninfectious forms of the disease. With a more detailed understanding of the immune mechanisms leading to the development of uveitis, we are now able to develop new therapeutic approaches based on targeting various components of the immune response.
Author Affiliations
From the National Eye Institute, National Institutes of Health, Bethesda, Md.
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati  Twitter
What's this?
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
Inhibitory peptide analogs derived from a major uveitogenic epitope protect from antiretinal autoimmunity by inducing type 2 and regulatory T cells
Cortes et al.
J. Leukoc. Biol. 2008;84:577-585.
ABSTRACT
| FULL TEXT
Unique Gene Expression Profiles of Donor-Matched Human Retinal and Choroidal Vascular Endothelial Cells
Smith et al.
IOVS 2007;48:2676-2684.
ABSTRACT
| FULL TEXT
An Interleukin (IL)-10/IL-12 Immunoregulatory Circuit Controls Susceptibility to Autoimmune Disease
Segal et al.
JEM 1998;187:537-546.
ABSTRACT
| FULL TEXT
|
