Occult choroidal neovascularization in age-related macular degeneration. A natural history study
T. S. Stevens, N. M. Bressler, M. G. Maguire, S. B. Bressler, S. L. Fine, J. Alexander, D. A. Phillips, R. R. Margherio, P. L. Murphy and A. P. Schachat
Department of Ophthalmology, University of Wisconsin-Madison, USA.
OBJECTIVE: To explore morphological and vision changes in untreated eyes
with subfoveal choroidal neovascularization (CNV) that have poorly
demarcated boundaries. DESIGN: Analysis of photographs of untreated
patients with poorly demarcated occult CNV participating in a prospective
clinical trial evaluating laser treatment compared with observation.
SETTING: Two tertiary retinal referral centers. PATIENTS: Symptomatic
individuals with poorly demarcated subfoveal occult CNV associated with
age-related macular degeneration. MAIN OUTCOME MEASURES: Change in size of
lesion, development of classic CNV, change in vision, and development of
subretinal fibrosis. RESULTS: During follow-up (9-12 months), 32% of the
occult choroidal neovascular lesions more than doubled their original size.
Classic CNV developed in 52% of eyes that started without it. The median
loss in visual acuity was 2.5 lines. Eyes with classic CNV or subretinal
blood or both at baseline developed subretinal fibrosis more frequently and
lost more visual acuity, but not to a statistically significant degree.
CONCLUSIONS: The morphological changes of eyes with subfoveal occult CNV in
which the boundaries are poorly demarcated in variable; the presence of
subretinal blood or a component of classic CNV may influence the prognosis
for further loss of vision.
Incident Choroidal Neovascularization in Fellow Eyes of Patients With Unilateral Subfoveal Choroidal Neovascularization Secondary to Age-Related Macular Degeneration: SST Report No. 20 From the Submacular Surgery Trials Research Group
Submacular Surgery Trials Research Group
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Eligibility for treatment and angiographic features at the early stage of exudative age related macular degeneration
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