Non-Hodgkin lymphoma and Kaposi sarcoma in an eyelid of a patient with acquired immunodeficiency syndrome. Multiple viruses in pathogenesis
M. Tunc, M. L. Simmons, D. H. Char and B. Herndier
Department of Ophthalmology, University of California, San Francisco, USA. mtunc@itsa.ucsf.edu
A 36-year-old patient with acquired immunodeficiency syndrome sought care
because of an upper eyelid lesion that dramatically increased in size. The
histopathologic examination revealed a high-grade diffuse large cell
non-Hodgkin lymphoma in continuity with a Kaposi sarcoma. In situ
hybridization revealed Epstein-Barr virus in the large cell lymphoma and
Kaposi sarcoma-associated herpesvirus in the Kaposi sarcoma lesion. This
collision tumor is an unusual presentation of 2 malignant neoplasms in a
patient with acquired immunodeficiency syndrome, with in situ hybridization
evidence of Epstein-Barr virus and Kaposi sarcoma-associated herpesvirus in
the lesion.
