Quantitative videographic analysis of blinking in normal subjects and patients with dry eye
K. Tsubota, S. Hata, Y. Okusawa, F. Egami, T. Ohtsuki and K. Nakamori
Department of Ophthalmology, Tokyo Dental College, Chiba, Japan.
OBJECTIVE: To study patterns of eye blinking in normal subjects and
patients with dry eye. METHODS: We developed an automated, noninvasive
blink monitor that permits quantitative analysis of 6 parameters of
blinking. We used this method under normal conditions and then examined the
effects on the patterns of blinking in patients with dry eye; several steps
in this method were designed to exacerbate or ameliorate ocular surface
desiccation. RESULTS: The mean (+/-SD), maximum, and coefficient of
variation of the interblinking time in normal subjects and patients with
dry eye were 4.0 +/- 2.0 and 1.5 +/- 0.9 seconds, 8.9 +/- 4.0 and 4.2 +/-
2.4 seconds, and 55% +/- 21% and 65% +/- 24%, respectively. Those values
for the blinking time were 0.20 +/- 0.04 and 0.27 +/- 0.16 seconds, 0.35
+/- 0.12 and 0.99 +/- 1.30 seconds, and 23% +/- 9% and 46% +/- 34%,
respectively. The use of artificial tears or spectacles with moist panels
and moist inserts tended to normalize the patterns of blinking in the
patients with dry eye, whereas exposure to wind made them more abnormal.
CONCLUSIONS: Our technique permitted a rigorous analysis of blinking that
was previously unavailable. We have shown that local ocular surface
conditions alone can significantly affect patterns of blinking. This method
should be applicable to studying psychologic and any other factors that may
influence blinking.
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