Indocyanine Green-Guided Laser Photocoagulation of Focal Spots at the Edge of Plaques of Choroidal Neovascularization
David R. Guyer, MD;
Lawrence A. Yannuzzi, MD;
loannis Ladas, MD;
Jason S. Slakter, MD;
John A. Sorenson, MD;
Dennis Orlock, CRA
Arch Ophthalmol. 1996;114(6):693-697.
Abstract
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Objective
To determine whether indocyanine green—guided laser photocoagulation of focal spots at the edge of plaques of neovascularization is beneficial for patients with untreatable occult choroidal neovascularization by fluorescein imaging.
Patients
A pilot series of 23 eyes were identified that had untreatable occult choroidal neovascularization secondary to age-related macular degeneration with focal spots at the edge of a plaque of neovascularization on the indocyanine green study. After informed consent was obtained,indocyanine green-guided laser photocoagulation was applied solely to the focal spot at the edge of the plaque.
Results
Anatomical success with resolution of the exudative findings was noted in 15 (79%) of 19 eyes at 6 months, 13 (68%) of 19 eyes at 12 months, and six (37.5%) of 16 eyes at 24 months. The median follow-up period was 18 months (range, 3 to 44 months). Visual acuity was stabilized or improved in nine (69%) of 13 successfully treated eyes at 1 year. Of the successfully treated cases at 1 year, nine (69%) of 13 had a final visual acuity of 20/100 or better.
Conclusions
Our preliminary study of indocyanine green-guided laser photocoagulation of focal spots at the edge of plaques of neovascularization suggests that this technique may improve the visual prognosis of these patients with presently untreatable disease. A prospective, randomized, controlled clinical trial is warranted to evaluate this treatment approach.
Author Affiliations
From the Retinal Research Laboratory, Manhattan Eye, Ear & Throat Hospital, New York, NY. The authors have no proprietary interest in the companies or products mentioned in this article.
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