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Zeev Stegman, MD; Joseph Sokol, MD; Jeffrey M. Liebmann, MD; Henry Cohen, MPH; Celso Tello, MD; Robert Ritch, MD

Arch Ophthalmol. 1996;114(6):660-663.

Abstract
Objective
To compare trabecular meshwork height in a series of patients with juvenile primary open-angle glaucoma (JPOAG) with that in normal control patients.

Methods
Ultrasound biomicroscopy and A-scan biometry were performed on 16 eyes with JPOAG and 24 normal eyes. A radial, perpendicular image in the horizontal temporal meridian detailing the line of Schwalbe, scleral spur, and angle anatomy was obtained for each eye by a single examiner. Trabecular meshwork height was defined as the distance from the scleral spur to the Schwalbe line.

Results
Mean patient age (P=.85, t test), refractive error (P=.68), sex distribution (P=.26, Fisher exact test) and axial length (P=.39) were similar between the groups. Mean±SE trabecular meshwork heights were 0.36±0.03 mm (range, 0.19-0.53 mm) for JPOAG and 0.58±0.02 mm (range, 0.40-0.80 mm) for controls (P<.001). Eyes with greater axial length tended to have larger trabecular meshworks in both groups (P=.012, multivariate regression). A trabecular meshwork height-axial length ratio of 0.021 or less was associated with a significantly increased risk for JPOAG being present (odds ratio, 57; 95% confidence interval, 6.0-541).

Conclusion
The trabecular meshwork is smaller in eyes with JPOAG compared with that in normal eyes. This finding suggests a structural abnormality that may underlie the reduced outflow.

Author Affiliations
From the Departments of Ophthalmology, The New York Eye and Ear Infirmary, New York, and The New York Medical College, Valhalla (Drs Stegman, Sokol, Liebmann, Tello, and Ritch), and Laboratory of Epidemiology and Biostatistics, Department of Environmental Medicine, New York University School of Medicine, New York (Dr Cohen). The authors have no financial interest in any facet of this manuscript.

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