This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Citing articles on Web of Science (98)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

The Eye Disease Case-Control Study Group

Arch Ophthalmol. 1996;114(5):545-554.

Abstract
Objective
To identify possible risk factors for central retinal vein occlusion (CRVO).

Design
Between May 1,1986, and December 31,1990, 258 patients with CRVO and 1142 controls were identified at five clinical centers. Data were obtained through interviews, clinical examinations, and laboratory analyses of blood specimens.

Results
An increased risk of CRVO was found in persons with systemic hypertension, diabetes mellitus, and open-angle glaucoma. Risk of CRVO decreased with increasing levels of physical activity and increasing levels of alcohol consumption. In women, risk of occlusion decreased with use of postmenopausal estrogens and increased with higher erythrocyte sedimentation rates. Cardiovascular disease, electrocardiographic abnormalities, history of treatment of diabetes mellitus, higher blood glucose levels, lower albumin-globulin ratios, and higher 1-globulin levels were associated with increased risk only for ischemic CRVO. Systemic hypertension was associated with increased risk for ischemic and nonischemic CRVO, but odds ratios were greater for the ischemic type.

Conclusions
Our results suggest a cardiovascular risk profile for persons with CRVO, in particular, patients with the ischemic type. The findings reinforce recommendations to diagnose and treat systemic hypertension, advise patients to increase physical exercise, and consider use of exogenous estrogens in postmenopausal women.

Author Affiliations
From the Division of Biometry and Epidemiology, National Eye Institute, Bethesda, Md. A list of investigators in The Eye Disease Case-Control Study Group appears on page 548.

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Ocular Associations of Diabetes Other Than Diabetic Retinopathy
Jeganathan et al.
Diabetes Care 2008;31:1905-1912.
FULL TEXT  

Retinal Vein Occlusion and Traditional Risk Factors for Atherosclerosis
O'Mahoney et al.
Arch Ophthalmol 2008;126:692-699.
ABSTRACT | FULL TEXT  

Efficacy of intravitreal triamcinolone for macular oedema due to CRVO after anti-androgen therapy for hirsutism in a young monocular female
Al-Dhibi et al.
Br J Ophthalmol 2007;91:1564-1565.
FULL TEXT  

Glucose-6-Phosphate Dehydrogenase Deficiency in Retinal Vein Occlusion
Pinna et al.
IOVS 2007;48:2747-2752.
ABSTRACT | FULL TEXT  

Retinal vein pulsation predicts increasing optic disc excavation
Nicolela
Br J Ophthalmol 2007;91:405-406.
FULL TEXT  

Ten-year incidence of retinal vein occlusion in an older population: the blue mountains eye study.
Cugati et al.
Arch Ophthalmol 2006;124:726-732.
ABSTRACT | FULL TEXT  

The future of glaucoma clinics
Morley and Murdoch
Br J Ophthalmol 2006;90:640-645.
ABSTRACT | FULL TEXT  

Radial Optic Neurotomy in the Porcine Eye Without Retinal Vein Occlusion
Czajka et al.
Arch Ophthalmol 2004;122:1185-1189.
ABSTRACT | FULL TEXT  

In Vivo Evaluation of Retinal Injury After Transient Ischemia in Hypertensive Rats
Hirose et al.
Hypertension 2004;43:1098-1102.
ABSTRACT | FULL TEXT  

Preventing Visual Loss From Chronic Eye Disease in Primary Care: Scientific Review
Rowe et al.
JAMA 2004;291:1487-1495.
ABSTRACT | FULL TEXT  

Clinical Course of Younger Patients With Central Retinal Vein Occlusion
Recchia et al.
Arch Ophthalmol 2004;122:317-321.
ABSTRACT | FULL TEXT  

Chorioretinal Anastomosis After Radial Optic Neurotomy for Central Retinal Vein Occlusion
Garcia-Arumi et al.
Arch Ophthalmol 2003;121:1385-1391.
ABSTRACT | FULL TEXT  

Vision-Related Quality of Life in People With Central Retinal Vein Occlusion Using the 25-Item National Eye Institute Visual Function Questionnaire
Deramo et al.
Arch Ophthalmol 2003;121:1297-1302.
ABSTRACT | FULL TEXT  

Influence of factor V Leiden on the development of neovascularisation secondary to central retinal vein occlusion
Hvarfner et al.
Br J Ophthalmol 2003;87:305-306.
ABSTRACT | FULL TEXT  

Follow up by colour Doppler imaging of 102 patients with retinal vein occlusion over 1 year
Arsene et al.
Br J Ophthalmol 2002;86:1243-1247.
ABSTRACT | FULL TEXT  

Thrombophilic Causes of Retinal Vascular Thrombosis: Etiology and Treatment Outcomes
Bick et al.
CLIN APPL THROMB HEMOST 2002;8:315-318.
 

Clinical characteristics of retinal venous occlusions occurring at different sites
Beaumont and Kang
Br J Ophthalmol 2002;86:572-580.
ABSTRACT | FULL TEXT  

Bilateral Central Retinal Vein Occlusion in a Patient With Occult Colon Cancer
Segev et al.
Arch Ophthalmol 2001;119:1552-1553.
FULL TEXT  

Thrombophilia: genetic polymorphisms and their association with retinal vascular occlusive disease
CHAK et al.
Br J Ophthalmol 2001;85:883-886.
FULL TEXT  

Administration of 17{beta}-Estradiol Attenuates Retinal Ischemia-Reperfusion Injury in Rats
Nonaka et al.
IOVS 2000;41:2689-2696.
ABSTRACT | FULL TEXT  

A systematic review of drug induced ocular reactions in diabetes
Hampson and Harvey
Br J Ophthalmol 2000;84:144-149.
ABSTRACT | FULL TEXT  

Raised plasma homocysteine as a risk factor for retinal vascular occlusive disease
Cahill et al.
Br J Ophthalmol 2000;84:154-157.
ABSTRACT | FULL TEXT  

Case-Control Designs for Clinical Research in Ophthalmology
Moy
Arch Ophthalmol 1998;116:661-664.
FULL TEXT  

Plasma endothelin-1 concentrations in patients with retinal vein occlusions
Iannaccone et al.
Br J Ophthalmol 1998;82:498-503.
ABSTRACT | FULL TEXT  

Aging and the pathogenesis of retinal vein thrombosis
GREAVES
Br J Ophthalmol 1997;81:810-811.
FULL TEXT  

Central retinal vein occlusion: what's the story?
WILLIAMSON
Br J Ophthalmol 1997;81:698-704.
FULL TEXT