This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Citing articles on Web of Science (13)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Robert D. Bourke, FRACO, FRACS; R. Nigel Simpson, PhD; Robert J. Cooling, FRCOphth, FRCS; Janet R. Sparrow, PhD

Arch Ophthalmol. 1996;114(5):537-544.

Abstract
Objectives
To examine the propensity for intraoperative procedures, such as endolaser, to generate polar impurities in perfluorocarbon liquids, either by degradation of the compound or by dissolution of materials contacting the liquid, given the value of these liquids as adjuncts to vitreoretinal procedures and the importance of using pure and inert liquid.

Methods
Perfluoro-N-octane liquid recovered from patients after vitreoretinal procedures was analyzed by gas chromatography, nuclear magnetic resonance, ultraviolet spectroscopy, and a cell proliferation assay. Similar analyses were performed on pure and impure perfluoro-N-octane exposed in vitro to superclinical energy levels of argon and YAG laser, endodiathermy, and endoillumination.

Results
No change in chemical structure and only minor (parts per million) increases in dissolved contaminants were observed. The perfluoro-N-octane liquid retained its inertness as indicated by the inability of fibroblasts to attach and proliferate on its surface.

Conclusion
The structure and biologic inactivity of perfluoro-N-octane are unaffected by vitreoretinal surgical manipulations.

Author Affiliations
From the Moorfields Eye Hospital, London, England (Drs Bourke and Cooling); Royal Brisbane (Australia) Hospital (Dr Bourke); Fluorosystems Ltd, Bristol, England (Dr Simpson); and Department of Ophthalmology, Cornell University Medical College, New York, NY (Dr Sparrow). Dr Simpson is a director of Fluorosystems Ltd. The other authors do not have a proprietary interest in perfluoro-N-octane.

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Displacement of Retained Subfoveal Perfluorocarbon Liquid After Vitreoretinal Surgery
Le Tien et al.
Arch Ophthalmol 2008;126:98-101.
ABSTRACT | FULL TEXT  

CT Characteristics of Intraocular Perfluoro-N-Octane
Christoforidis et al.
Am. J. Neuroradiol. 2003;24:1769-1771.
ABSTRACT | FULL TEXT  

Use of perfluorocarbon liquid during vitrectomy for severe proliferative diabetic retinopathy
Imamura et al.
Br J Ophthalmol 2003;87:563-566.
ABSTRACT | FULL TEXT