You are seeing this message because your Web browser does not support basic Web standards. Find out more about why this message is appearing and what you can do to make your experience on this site better.


ABOUT ARCHIVES
Advanced Search

Welcome   | My Account | E-mail Alerts | Access Rights | Sign In


  Vol. 114 No. 4, April 1996 TABLE OF CONTENTS
  Archives
  •  Online Features
  ARTICLE
 This Article
 • Reply to article
 •Send to a friend
 • Save in My Folder
 •Save to citation manager
 •Permissions
 Citing Articles
 •Citation map
 •Citing articles on HighWire
 •Contact me when this article is cited
 Related Content
 •Similar articles in this journal

Clinicopathologic correlation of submacular membranectomy with retention of good vision in a patient with age-related macular degeneration

R. H. Rosa, M. A. Thomas and W. R. Green
Eye Pathology Laboratory, Wilmer Institute, The Johns Hopkins Medical Institutions, Baltimore, Md., USA.

We present the clinicopathologic features of the eye of a patient with age-related macular degeneration who underwent submacular membranectomy and had retention of good visual acuity for almost 4 years despite recurrent choroidal neovascularization treated with krypton laser photocoagulation and mild expansion of the laser lesion with time. Histopathologic study of the surgically removed membrane from the right eye disclosed a thin fibrovascular membrane lined by retinal pigment epithelium on one surface. Microscopic examination of the right eye obtained post mortem disclosed a 2.75-mm (horizontal) x 2.1-mm (vertical) retinal pigment epithelium defect with overlying photoreceptor cell atrophy centered on the temporal parafoveal area, and a 0.6 x 0.1-mm subretinal pigment epithelium fibrovascular membrane with an area of retinal pigment epithelial hyperplasia and vascularization from the retina 0.4 mm temporal to the fovea. Basal laminar deposit was present in the region of the fovea and nasal parafoveal area.

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Histopathologic and Ultrastructural Features of Surgically Excised Subfoveal Choroidal Neovascular Lesions: Submacular Surgery Trials Report No. 7
Submacular Surgery Trials Research Group
Arch Ophthalmol 2005;123:914-921.
ABSTRACT | FULL TEXT  

Iris Pigment Epithelium Attachment to Aged Submacular Human Bruch's Membrane
Itaya et al.
IOVS 2004;45:4520-4528.
ABSTRACT | FULL TEXT  

Retinal Pigment Epithelium Wound Healing in Human Bruch's Membrane Explants
Wang et al.
IOVS 2003;44:2199-2210.
ABSTRACT | FULL TEXT  

Correlation of Histologic 2-Dimensional Reconstruction and Confocal Scanning Laser Microscopic Imaging of Choroidal Neovascularization in Eyes With Age-Related Maculopathy
Grossniklaus et al.
Arch Ophthalmol 2000;118:625-629.
ABSTRACT | FULL TEXT  

Basal Linear Deposit and Large Drusen Are Specific for Early Age-Related Maculopathy
Curcio and Millican
Arch Ophthalmol 1999;117:329-339.
ABSTRACT | FULL TEXT  

Transplanted and repopulated retinal pigment epithelial cells on damaged Bruch's membrane in rabbits
Shiragami et al.
Br. J. Ophthalmol. 1998;82:1056-1062.
ABSTRACT | FULL TEXT  

Reattachment Rate of Human Retinal Pigment Epithelium to Layers of Human Bruch's Membrane
Del Priore and Tezel
Arch Ophthalmol 1998;116:335-341.
ABSTRACT | FULL TEXT  





HOME | CURRENT ISSUE | PAST ISSUES | TOPIC COLLECTIONS | CME | SUBMIT | SUBSCRIBE | HELP
CONDITIONS OF USE | PRIVACY POLICY | CONTACT US | SITE MAP
 
© 1996 American Medical Association. All Rights Reserved.