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A Clinicopathologic Study

Faruque Ghanchi, FRCOphth; Andrew Ramsay, FRCOphth; Sarah Coupland, MBBS; Dai Barr, FRCOphth; William R. Lee, MD

Arch Ophthalmol. 1996;114(3):341-345.

Abstract
Tumoral calcinosis is a rare systemic disorder characterized by para-articular ectopic soft-tissue calcification. This case report describes the ophthalmic features (palpebral conjunctival calcific nodules, the white limbal girdle of Vogt, disc drusen, and angioid streaks) in a 38-year-old Asian woman who had tumoral calcinosis associated with hyperphosphatemia. A morphologic study of the calcified nodules on the palpebral conjunctiva disclosed deposition of hydroxyapatite crystals in an extracellular matrix (deposit) containing alcianophilic mucopolysaccharides. Excision of the eyelid nodules was not followed by recurrence.

Author Affiliations
From the Tennent Institute of Ophthalmology (Drs Ghanchi, Ramsay, and Barr), and the Department of Pathology (Drs Coupland and Lee), Western Infirmary, Glasgow, Scotland.

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