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  Vol. 114 No. 11, November 1996 TABLE OF CONTENTS
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Immunocytochemical features of retinoblastoma in an adult

T. M. Nork, L. L. Millecchia, G. B. de Venecia, F. L. Myers and K. A. Vogel
Department of Ophthalmology and Visual Sciences, University of Wisconsin Medical School, Madison, USA. nork@eyesee.ophth.wisc.edu

OBJECTIVE: To describe the clinical course and immunocytochemical characteristics of an unusual intraocular tumor. METHODS: Immunocytochemical analysis of the enucleated eye with an intraocular mass that markedly waxed and waned in size during 1 year of close observation of a 29-year-old woman. RESULTS: Most of the tumor was composed of either dying or rapidly proliferating cells. One area located near the retina consisted mostly of well-differentiated cells in uniform sheets (bacillettes) with lacelike glial processes between the tumor cells. Almost all of the differentiated tumor cells were positive for S antigen. In particular, the dominant cell type stained positively for both antibodies known to be specific for those isoforms of S antigen found only in blue cones and rods but not in red or green cones. Only a few of these cells labeled positively with an anti-rhodopsin antibody. CONCLUSIONS: This is the first case of adult retinoblastoma to be confirmed immunocytochemically. The tumor was unusual because the differentiated regions contained bacillettes composed mostly of blue cones. It is possible that this and other adult retinoblastomas may arise from previously existing retinocytomas.

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Observations on 17 Patients With Retinocytoma
Singh et al.
Arch Ophthalmol 2000;118:199-205.
ABSTRACT | FULL TEXT  





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