This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Citing articles on Web of Science (61)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

From the Cell Biology of the 1990s to the Ophthalmology of the 21st Century?

Ruben Adler, MD

Arch Ophthalmol. 1996;114(1):79-83.

Abstract
There is still no effective treatment for retinal degenerative diseases such as retinitis pigmentosa (RP), in which the loss of photoreceptor cells causes visual loss and eventually blindness. In addition to its intrinsic scientific interest, basic research aimed at elucidating the biological mechanisms regulating the survival and function of cones and rods is also important from a clinical perspective, since it could provide a foundation for the development of therapeutic strategies for these diseases. The recent observation that photoreceptor degeneration in several RP animal models occurs through programmed cell death (apoptosis) illustrates this possibility well. This article will present a brief overview of recent research contributions toward the search for treatments for retinal degenerations of genetic origin.

Author Affiliations
From the Wilmer Ophthalmological Institute, The Johns Hopkins University School of Medicine, Baltimore, Md.

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

How to keep photoreceptors alive
Bird
Proc. Natl. Acad. Sci. USA 2007;104:2033-2034.
FULL TEXT  

Transgenic Expression of IGF-1 Modifies the Proliferative Potential of Human Retinal Pigment Epithelial Cells
Chaum and Yang
IOVS 2002;43:3758-3764.
ABSTRACT | FULL TEXT  

Apoptotic cell death of cultured salamander photoreceptors induced by cccp: CsA-insensitive mitochondrial permeability transition
Yang et al.
J. Cell Sci. 2001;114:1655-1664.
ABSTRACT  

Impairment of Rod cGMP-Gated Channel {alpha}-Subunit Expression Leads to Photoreceptor and Bipolar Cell Degeneration
Leconte and Barnstable
IOVS 2000;41:917-926.
ABSTRACT | FULL TEXT  

Synergy of Activin and Ciliary Neurotrophic Factor Signaling Pathways in the Induction of Vasoactive Intestinal Peptide Gene Expression
Symes et al.
Mol. Endocrinol. 2000;14:429-439.
ABSTRACT | FULL TEXT  

Inhibition of Caspase Activity in Retinal Cell Apoptosis Induced by Various Stimuli In Vitro
Tezel and Wax
IOVS 1999;40:2660-2667.
ABSTRACT | FULL TEXT  

Regulation of sorting and post-Golgi trafficking of rhodopsin by its C-terminal sequence QVS(A)PA
Deretic et al.
Proc. Natl. Acad. Sci. USA 1998;95:10620-10625.
ABSTRACT | FULL TEXT  

Normal retina releases a diffusible factor stimulating cone survival in the retinal degeneration mouse
Mohand-Said et al.
Proc. Natl. Acad. Sci. USA 1998;95:8357-8362.
ABSTRACT | FULL TEXT  

Disease sequence from mutant rhodopsin allele to rod and cone photoreceptor degeneration in man
Cideciyan et al.
Proc. Natl. Acad. Sci. USA 1998;95:7103-7108.
ABSTRACT | FULL TEXT  

Expression, stability, and membrane integration of truncation mutants of bovine rhodopsin
Heymann and Subramaniam
Proc. Natl. Acad. Sci. USA 1997;94:4966-4971.
ABSTRACT | FULL TEXT  

Mechanisms of Photoreceptor Death in Retinal Degenerations: From the Cell Biology of the 1990s to the Ophthalmology of the 21 st Century?
Crane
Arch Ophthalmol 1996;114:1158-1158.
ABSTRACT