 |
 |

Biochemical Factors in the Lens Opacities Case-Control Study
M. Cristina Leske, MD, MPH;
Suh-Yuh Wu, MA;
Leslie Hyman, PhD;
Robert Sperduto, MD;
Barbara Underwood, PhD;
Leo T. Chylack, MD;
Roy C. Milton, PhD;
Satish Srivastava, PhD;
Naseem Ansari, PhD;
The Lens Opacities Case-Control Study Group
Arch Ophthalmol. 1995;113(9):1113-1119.
Abstract
 |  |
Objective To evaluate associations with biochemical indicators of nutritional and other risk factors in the Lens Opacities Case-Control Study.
Design Case-control study.
Setting and Participants The Lens Opacities CaseControl Study determined risk factors for cortical, nuclear, and posterior subcapsular opacities among 1380 participants aged 40 to 79 years.
Data Collection Vitamin E, selenium, and biochemistry profile determinations were performed on all patients; red blood cell enzymes and amino acids were measured in systematic samples of about25% of the Lens Opacities Case-Control Study population.
Outcome Laboratory test values in cases and controls were compared and expressed as odds ratios and 95% confidence intervals.
Results In polychotomous logistic regression analyses controlling for age and sex, the risk of opacities was reduced to less than one half in persons with higher levels of vitamin E (odds ratio, 0.44 for nuclear opacities), albumin-globulin ratio (odds ratio, 0.41 for mixed opacities), or iron (odds ratio, 0.43 for cortical opacities); higher uric acid levels increased risk (odds ratio, 1.74 for mixed opacities). Persons with opacities were twice as likely to have high glutathione reductase activity (with flavin adenine dinucleotide), which suggests low riboflavin status (odds ratio, 2.13). Most odds ratios for amino acids were under unity and were significantly decreased for glycine (0.36) and aspartic acid (0.31).
Conclusions Lens opacities were associated with lower levels of riboflavin, vitamin E, iron, and protein nutritional status. Higher levels of uric acid increased risk of mixed opacities. The findings for riboflavin, vitamin E, iron, and uric acid are compatible with the dietary intake and medical history results of the Lens Opacities Case-Control Study.
Author Affiliations
From the Division of Epidemiology, Department of Preventive Medicine, State University of New York at Stony Brook (Drs Leske and Hyman and Ms Wu); Office of Biometry and Epidemiology, National Eye Institute, Bethesda, Md (Drs Sperduto and Milton); World Health Organization, Geneva, Switzerland (Dr Underwood); Department of Ophthalmology, Harvard Medical School and the Division of Ophthalmology, Department of Surgery, Brigham and Women's Hospital, Boston, Mass (Dr Chylack); and Division of Human Genetics, Department of Human Biological Chemistry and Genetics, University of Texas Medical Branch, Galveston (Drs Srivastava and Ansari). Members of The Lens Opacities Case-Control Study Group are listed in Archives of Ophthalmology (1991;109:251).
CiteULike Connotea Del.icio.us Digg Reddit Technorati Twitter
What's this?
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
 |
Prospective Epidemiological Cohort Study of Reduced Risk for Incident Cataract with Vigorous Physical Activity and Cardiorespiratory Fitness during a 7-Year Follow-up
Williams
IOVS 2009;50:95-100.
ABSTRACT
| FULL TEXT
Blood Levels of Vitamin C, Carotenoids and Retinol Are Inversely Associated with Cataract in a North Indian Population
Dherani et al.
IOVS 2008;49:3328-3335.
ABSTRACT
| FULL TEXT
The Antioxidants in Prevention of Cataracts Study: effects of antioxidant supplements on cataract progression in South India
Gritz et al.
Br J Ophthalmol 2006;90:847-851.
ABSTRACT
| FULL TEXT
Statin Use and Incident Nuclear Cataract
Klein et al.
JAMA 2006;295:2752-2758.
ABSTRACT
| FULL TEXT
Long-term Nutrient Intake and 5-Year Change in Nuclear Lens Opacities
Jacques et al.
Arch Ophthalmol 2005;123:517-526.
ABSTRACT
| FULL TEXT
Albumin and Transthyretin as Risk Factors for Cataract: The POLA Study
Delcourt et al.
Arch Ophthalmol 2005;123:225-232.
ABSTRACT
| FULL TEXT
Low Vitamin E Level as a Subliminal Risk Factor in a Rat Model of Prednisolone-Induced Cataract
Kojima et al.
IOVS 2002;43:1116-1120.
ABSTRACT
| FULL TEXT
Long-term intake of vitamins and carotenoids and odds of early age-related cortical and posterior subcapsular lens opacities
Taylor et al.
Am. J. Clin. Nutr. 2002;75:540-549.
ABSTRACT
| FULL TEXT
A Randomized, Placebo-Controlled, Clinical Trial of High-Dose Supplementation With Vitamins C and E and Beta Carotene for Age-Related Cataract and Vision Loss: AREDS Report No. 9
Age-Related Eye Disease Study Research Group
Arch Ophthalmol 2001;119:1439-1452.
ABSTRACT
| FULL TEXT
Relations of body fat distribution and height with cataract in men
Schaumberg et al.
Am. J. Clin. Nutr. 2000;72:1495-1502.
ABSTRACT
| FULL TEXT
Serum carotenoids and tocopherols and incidence of age-related nuclear cataract
Lyle et al.
Am. J. Clin. Nutr. 1999;69:272-277.
ABSTRACT
| FULL TEXT
Prevalence of Lens Opacities in the Barbados Eye Study
Leske et al.
Arch Ophthalmol 1997;115:105-111.
ABSTRACT
|