You are seeing this message because your Web browser does not support basic Web standards. Find out more about why this message is appearing and what you can do to make your experience on this site better.


ABOUT ARCHIVES
Advanced Search

Welcome   | My Account | E-mail Alerts | Access Rights | Sign In


  Vol. 113 No. 7, July 1995 TABLE OF CONTENTS
  Archives
  •  Online Features
  ARTICLE
 This Article
 • Reply to article
 •Send to a friend
 • Save in My Folder
 •Save to citation manager
 •Permissions
 Citing Articles
 •Citation map
 •Citing articles on HighWire
 •Contact me when this article is cited
 Related Content
 •Similar articles in this journal

Risk factors for open-angle glaucoma. The Barbados Eye Study

M. C. Leske, A. M. Connell, S. Y. Wu, L. G. Hyman and A. P. Schachat
Department of Preventive Medicine, State University of New York at Stony Brook, USA.

OBJECTIVE: To evaluate risk factors for open-angle glaucoma among black participants in the Barbados Eye Study. DESIGN: Population-based study of demographic, medical, ocular, familial, and other factors possibly related to open-angle glaucoma. SETTING AND PARTICIPANTS: The Barbados Eye Study included 4709 Barbados residents identified by a simple random sample of Barbadian-born citizens, 40 to 84 years of age; participation was 84%. This report is based on the 4314 black participants examined at the study site; 302 (7%) met the Barbados Eye Study criteria for open-angle glaucoma. DATA COLLECTION: A standardized protocol included applanation tonometry, Humphrey perimetry, fundus photography, blood pressure, anthropometry, and an interview. An ophthalmologic examination was performed for participants who met specific criteria. MAIN OUTCOME MEASURES: Open-angle glaucoma was defined by the presence of both characteristic visual field defects and optic disc damage. Association of open-angle glaucoma with specific factors was evaluated in logistic regression analyses. RESULTS: Age, male gender, high intraocular pressure, and family history of open-angle glaucoma were major risk factors; the latter association was stronger in men than women. Lean body mass and cataract history were the only other factors related to open-angle glaucoma. Although hypertension and diabetes were common in Barbados Eye Study participants, they were unrelated to the prevalence of open-angle glaucoma. However, associations were found with low diastolic blood pressure-intraocular pressure differences and low systolic and diastolic blood pressure/intraocular pressure ratios. CONCLUSIONS: In the Barbados Eye Study black population, persons most likely to have open-angle glaucoma were older men and had a family history of open-angle glaucoma, high intraocular pressure, lean body mass, and cataract history. These results suggest the importance of possible genetic or familial factors in open-angle glaucoma. The role of vascular risk factors is consistent with our finding of low blood pressure to intraocular pressure relationships, but the results could be explained by the high intraocular pressure in open-angle glaucoma.

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Open-angle Glaucoma and Mortality: The Barbados Eye Studies
Wu et al.
Arch Ophthalmol 2008;126:365-370.
ABSTRACT | FULL TEXT  

Population Differences in Elastin Maturation in Optic Nerve Head Tissue and Astrocytes
Urban et al.
IOVS 2007;48:3209-3215.
ABSTRACT | FULL TEXT  

Blood Pressure, Arterial Stiffness, and Open-angle Glaucoma: The Rotterdam Study
Hulsman et al.
Arch Ophthalmol 2007;125:805-812.
ABSTRACT | FULL TEXT  

Mutant Myocilin Nonsecretion In Vivo Is Not Sufficient To Cause Glaucoma
Gould et al.
Mol. Cell. Biol. 2006;26:8427-8436.
ABSTRACT | FULL TEXT  

Nine-year changes in intraocular pressure: the barbados eye studies.
Wu et al.
Arch Ophthalmol 2006;124:1631-1636.
ABSTRACT | FULL TEXT  

Effects of Topical Hypotensive Drugs on Circadian IOP, Blood Pressure, and Calculated Diastolic Ocular Perfusion Pressure in Patients with Glaucoma.
Quaranta et al.
IOVS 2006;47:2917-2923.
ABSTRACT | FULL TEXT  

Prevalence of Open-Angle Glaucoma in a Rural South Indian Population
Vijaya et al.
IOVS 2005;46:4461-4467.
ABSTRACT | FULL TEXT  

Glaucoma: Macrocosm to Microcosm The Friedenwald Lecture
Quigley
IOVS 2005;46:2663-2670.
FULL TEXT  

Retinal Vessel Diameters and Incident Open-Angle Glaucoma and Optic Disc Changes: The Rotterdam Study
Ikram et al.
IOVS 2005;46:1182-1187.
ABSTRACT | FULL TEXT  

Central Corneal Thickness and Thickness of the Lamina Cribrosa in Human Eyes
Jonas and Holbach
IOVS 2005;46:1275-1279.
ABSTRACT | FULL TEXT  

The Influence of Various Substances on the Biomechanical Behavior of Lamina Cribrosa and Peripapillary Sclera
Spoerl et al.
IOVS 2005;46:1286-1290.
ABSTRACT | FULL TEXT  

Lamina Cribrosa Thickness and Spatial Relationships between Intraocular Space and Cerebrospinal Fluid Space in Highly Myopic Eyes
Jonas et al.
IOVS 2004;45:2660-2665.
ABSTRACT | FULL TEXT  

Risk Factors Associated with the Incidence of Open-Angle Glaucoma: The Visual Impairment Project
Le et al.
IOVS 2003;44:3783-3789.
ABSTRACT | FULL TEXT  

Factors Related to the 4-Year Risk of High Intraocular Pressure: The Barbados Eye Studies
Nemesure et al.
Arch Ophthalmol 2003;121:856-862.
ABSTRACT | FULL TEXT  

Intraocular pressure and visual field loss in primary angle closure and primary open angle glaucomas
Gazzard et al.
Br. J. Ophthalmol. 2003;87:720-725.
ABSTRACT | FULL TEXT  

Measuring Outcomes in Chronic Diseases: Ready for Prime Time?
Lee
Arch Ophthalmol 2003;121:712-714.
FULL TEXT  

Family Score as an Indicator of Genetic Risk of Primary Open-Angle Glaucoma
Hulsman et al.
Arch Ophthalmol 2002;120:1726-1731.
ABSTRACT | FULL TEXT  

Incident Open-Angle Glaucoma and Blood Pressure
Leske et al.
Arch Ophthalmol 2002;120:954-959.
ABSTRACT | FULL TEXT  

Distributions of p53 codon 72 polymorphism in primary open angle glaucoma
Lin et al.
Br. J. Ophthalmol. 2002;86:767-770.
ABSTRACT | FULL TEXT  

Glaucoma in Zulus: A Population-Based Cross-sectional Survey in a Rural District in South Africa
Rotchford and Johnson
Arch Ophthalmol 2002;120:471-478.
ABSTRACT | FULL TEXT  

The Prevalence of Glaucoma in a Population-Based Study of Hispanic Subjects: Proyecto VER
Quigley et al.
Arch Ophthalmol 2001;119:1819-1826.
ABSTRACT | FULL TEXT  

Incidence of Open-Angle Glaucoma: The Barbados Eye Studies
Leske et al.
Arch Ophthalmol 2001;119:89-95.
ABSTRACT | FULL TEXT  

Insights From Incidence: The Barbados Eye Studies
Musch
Arch Ophthalmol 2001;119:117-118.
FULL TEXT  

Relationship between intraocular pressure and obesity in Japan
Mori et al.
Int J Epidemiol 2000;29:661-666.
ABSTRACT | FULL TEXT  

Multivariate Approach for Quantification of Morphologic and Functional Damage in Glaucoma
Martus et al.
IOVS 2000;41:1099-1110.
ABSTRACT | FULL TEXT  

Fellow Eye Prognosis in Patients With Severe Visual Field Loss in 1 Eye From Chronic Open-Angle Glaucoma
Chen and Bhandari
Arch Ophthalmol 2000;118:473-478.
ABSTRACT | FULL TEXT  

The Relationship Between Glaucoma and Pseudoexfoliation: The Blue Mountains Eye Study
Mitchell et al.
Arch Ophthalmol 1999;117:1319-1324.
ABSTRACT | FULL TEXT  

Incidence of self reported glaucoma in people with diabetes mellitus
Klein et al.
Br. J. Ophthalmol. 1997;81:743-747.
ABSTRACT | FULL TEXT  





HOME | CURRENT ISSUE | PAST ISSUES | TOPIC COLLECTIONS | CME | SUBMIT | SUBSCRIBE | HELP
CONDITIONS OF USE | PRIVACY POLICY | CONTACT US | SITE MAP
 
© 1995 American Medical Association. All Rights Reserved.