This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Joel R. Ross, PhD; Gary N. Foulks, MD; Fred P. Sanfilippo, MD, PhD; David N. Howell, MD, PhD

Arch Ophthalmol. 1995;113(3):340-345.

Abstract
The pathogenesis of posterior polymorphous dystrophy was analyzed by immunohistologic methods. Sections of corneal buttons from two patients undergoing transplantation owing to posterior polymorphous dystrophy were stained with 2B4.14.1, a monoclonal antibody that reacts with human corneal endothelium, and with a cocktail of antihuman cytokeratin monoclonal antibodies that do not react with normal corneal endothelium. Single-stained sections revealed a variegated, intermittent staining pattern of antibody reactive and nonreactive cells. Double-stained sections revealed some cells that stained with only one of the antibodies and many cells that stained with both antibodies. The presence of cells staining positively for both 2B4.14.1 antigen and cytokeratins supports the hypothesis that the cytokeratin-expressing epithelial-like cells found in corneas with posterior polymorphous dystrophy arise via a metaplastic process in which the phenotype of endothelial cells becomes progressively abnormal.

Author Affiliations
From the Departments of Ophthalmology (Drs Ross and Foulks) and Pathology (Dr Howell), Durham (NC) Veterans Affairs Medical Center and Duke University Medical Center, Durham; and the Department of Pathology, The Johns Hopkins School of Medicine, Baltimore, Md (Dr Sanfilippo).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Missense mutations in COL8A2, the gene encoding the {alpha}2 chain of type VIII collagen, cause two forms of corneal endothelial dystrophy
Biswas et al.
Hum Mol Genet 2001;10:2415-2423.
ABSTRACT | FULL TEXT  

Ultrasound biomicroscopic images of the anterior chamber angle of a patient with posterior polymorphous dystrophy
KATAI et al.
Br J Ophthalmol 1998;82:1339-1339.
FULL TEXT  

Early-Onset Posterior Polymorphous Dystrophy
Levy et al.
Arch Ophthalmol 1996;114:1265-1268.
ABSTRACT