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Michael R. Hee, MS; Joseph A. Izatt, PhD; Eric A. Swanson, MS; David Huang, MD, PhD; Joel S. Schuman, MD; Charles P. Lin, PhD; Carmen A. Puliafito, MD; James G. Fujimoto, PhD

Arch Ophthalmol. 1995;113(3):325-332.

Abstract
Objective
To demonstrate optical coherence tomography for high-resolution, noninvasive imaging of the human retina. Optical coherence tomography is a new imaging technique analogous to ultrasound B scan that can provide cross-sectional images of the retina with micrometer-scale resolution.

Design
Survey optical coherence tomographic examination of the retina, including the macula and optic nerve head in normal human subjects.

Setting
Research laboratory.

Participants
Convenience sample of normal human subjects.

Main Outcome Measures
Correlation of optical coherence retinal tomographs with known normal retinal anatomy.

Results
Optical coherence tomographs can discriminate the cross-sectional morphologic features of the fovea and optic disc, the layered structure of the retina, and normal anatomic variations in retinal and retinal nerve fiber layer thicknesses with 10-µm depth resolution.

Conclusion
Optical coherence tomography is a potentially useful technique for high depth resolution, cross-sectional examination of the fundus.

Author Affiliations
From the Department of Electrical Engineering and Computer Science, Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge (Mr Hee and Drs Izatt, Huang, and Fujimoto); Harvard Medical School, Boston (Mr Hee); Lincoln Laboratoiy, Massachusetts Institute of Technology, Lexington (Mr Swanson); and the New England Eye Center, Tufts University School of Medicine, Boston (Drs Schuman, Lin, and Puliafito). Dr Huang is currently with the Doheny Eye Institute and Department of Ophthalmology, University of Southern California, Los Angeles. Drs Puliafito and Fujimoto are consultants for Humphrey Instruments, San Leandro, Calif.

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