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Lill-Inger Larsson, MD; Esther S. Rettig, MD; Richard F. Brubaker, MD

Arch Ophthalmol. 1995;113(3):283-286.

Abstract
Objectives
To measure aqueous dynamic variables in patients with open-angle glaucoma when their ocular hypotensive treatment was withdrawn and to determine if the circadian rhythm of the aqueous humor flow was present in open-angle glaucoma.

Methods
We studied 20 patients with open-angle glaucoma, and a group of 20 healthy subjects served as controls. Aqueous humor flow was measured by clearance of topically applied fluorescein with a fluorophotometer, tonography was used to measure outflow facility, and applanation tonometry was used to measure the intraocular pressure.

Results
We did not find any statistically significant difference when comparing aqueous flow during the daytime in subjects with open-angle glaucoma with that in controls. However, we did measure a higher aqueous flow at night in the group with open-angle glaucoma, compared with the normal group. The circadian rhythm of aqueous humor flow was present in the subjects with glaucoma.

Conclusions
Aqueous flow is not suppressed in glaucomatous eyes that are not undergoing treatment. Rather, the flow is slightly higher at night during sleep compared with the flow in normal sleeping subjects, but not high enough to have a clinically significant effect on intraocular pressure.

Author Affiliations
From the Department of Ophthalmology, Mayo Clinic and Mayo Foundation (Drs Larsson and Brubaker), and the Mayo Medical School (Dr Rettig), Rochester, Minn. Dr Larsson is currently with the Department of Ophthalmology, Uppsala University, Sweden, and Dr Rettig, with the Department of Ophthalmology, Mayo Clinic and Foundation.

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