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  Vol. 113 No. 12, December 1995 TABLE OF CONTENTS
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Pathologic human vitreous promotes contraction by fibroblasts. Implications for proliferative vitreoretinopathy

C. Hardwick, R. Morris, D. Witherspoon, M. White, R. Feist, R. McFarland and C. Guidry
Department of Ophthalmology, University of Alabama at Birmingham, USA.

OBJECTIVE: To establish and quantify the presence of contraction-stimulating activity in pathologic vitreous and correlate this activity with clinical presentation and outcome, especially with proliferative vitreoretinopathy. METHODS: Contraction-stimulating activity of vitreous collected during surgery was quantified with a tissue culture assay using fibroblasts as target cells. The activity of each sample was correlated with patient history, clinical presentation, risk factors, proliferative disease, and postoperative proliferation. RESULTS: Pathologic vitreous contained measurable quantities of contraction-stimulating activity and stimulated contraction in vitro, with elevated activities in samples from patients with proliferative vitreoretinopathy, epimacular proliferation, retinal detachment, retinal defects, pigmented cells in the vitreous, hemorrhage, or uveitis. Patients with postoperative proliferation had significantly elevated mean activities. CONCLUSIONS: Levels of contraction-stimulating activity in pathologic vitreous correlate with some risk factors for the development of proliferative vitreoretinopathy and may ultimately be useful in the assessment of disease severity and the prediction of postoperative proliferation.

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Tractional Force Generation by Porcine Muller Cells: Paracrine Stimulation by Retinal Pigment Epithelium
Mamballikalathil et al.
IOVS 2000;41:529-536.
ABSTRACT | FULL TEXT  





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