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Marjolein J. H. Ronday, MD; Leny Luyendijk, MS; G. Seerp Baarsma, MD; Jan-Geert Bollemeijer, MD; Allegonda Van der Lelij, MD; Aniki Rothova, MD

Arch Ophthalmol. 1995;113(12):1524-1529.

Abstract
Objective
To describe the clinical characteristics and laboratory findings of eight patients with focal chorioretinitis presumably caused by acquired toxoplasmosis.

Design
Case series.

Setting
Referral hospitals in the Netherlands.

Patients
Eight patients, aged 42 to 75 years, with unilateral focal chorioretinitis and laboratory evidence of a recently acquired infection with Toxoplasma gondii.

Main Outcome Measures
Findings from ocular examination and analysis of both serum and aqueous humor samples for Toxoplasma and viral antibodies.

Results
All patients had unilateral focal chorioretinitis without associated old scars in the posterior pole. Patients treated with systemic or periocular corticosteroids not accompanied by antiparasitic medication showed a rapid increase of inflammation. All eight patients had Toxoplasma IgM antibodies in their serum samples, seven of whom had high Toxoplasma IgG titers. Five of eight patients had increased intraocular production of IgG antibodies against T gondii.

Conclusion
Unilateral focal chorioretinitis in patients of any age should alert the clinician to consider acquired ocular toxoplasmosis in the differential diagnosis.

Author Affiliations
From the Netherlands Ophthalmic Research Institute, Amsterdam (Drs Ronday and Rothova and Ms Luyendijk); the Eye Hospital Rotterdam (Dr Baarsma); the Department of Ophthalmology, State University Leiden (Dr Bollemeijer); F. C. Donders Institute of Ophthalmology, Utrecht (Drs Van der Lelij and Rothova); and the Department of Ophthalmology, Academic Medical Centre, University of Amsterdam (Dr Rothova), the Netherlands.

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