 |
|
Silicone Oil in Repair of Retinal Detachments Caused by Necrotizing Retinitis in HIV Infection
Janet L. Davis, MD;
Michelle S. Serfass;
Mei-Ying Lai, MS;
Douglas K. Trask, MD;
Stanley P. Azen, PhD
Arch Ophthalmol. 1995;113(11):1401-1409.
Abstract
Objective
To evaluate the safety and efficacy of 1000-and 5000-centistoke silicone oil as retinal tamponades for the treatment of retinal detachments secondary to necrotizing retinitis in patients with human immunodeficiency virus (HIV) infection.
Design
A prospective observational study. Setting: Community and university-based ophthalmology clinics.
Patients
Three hundred fifty patients with HIV infection, who had 407 eyes with retinal detachments secondary to necrotizing retinitis.
Intervention
Vitrectomy surgery for retinal detachment with 1000- or 5000-centistoke silicone oil as the retinal tamponade.
Outcome Measures
Efficacy was measured both by anatomic success (defined as complete retinal attachment or macular attachment) and by visual acuity success (defined as preservation of visual acuity or ambulatory vision). Safety was determined by the rate of complications, including abnormal intraocular pressure and corneal and lens opacification.
Results
At the last follow-up examination, the retina was completely attached in 287 (73%) of 393 eyes, the macula was attached in 370 eyes (94%), 268 eyes (68%) had ambulatory vision, and visual acuity was preserved in 219 (56%) of 388 eyes. Corneal opacification, hypotony, and silicone oil emulsification were present in 4%, 2%, and 1% of eyes, respectively. One eye had elevated intraocular pressure. Of the 57 patients who had both eyes treated, 35 died, of whom four (11%) had nonambulatory vision in both eyes. Of the 293 patients who had one eye treated, 122 died, of whom 44 (36%) died with nonambulatory vision in the treated eye. The median time to cataract was 192 days; to nonambulatory vision, 474 days; and to death, 204 days.
Conclusions
Silicone oil repair of retinal detachments in necrotizing retinitis is an efficacious and safe procedure that delays or prevents loss of vision in advanced HIV disease.
Author Affiliations
From the Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami (Fla) School of Medicine (Dr Davis); Richard-James Inc, Peabody, Mass (Ms Serfass); Statistical Consultation and Research Center, Department of Preventive Medicine, University of Southern California, Los Angeles (Ms Lai and Dr Azen); and Department of Otolaryngology, University of Michigan, Ann Arbor (Dr Trask). The names of the participating investigators are included in a box at the end of this article. The authors are employees of (Ms Serfass and Dr Trask) and consultants for (Drs Davis and Azen) Richard-James Inc, which sponsored the collection of these data in preparation for a premarket approval application for silicone oil in the repair of retinal detachments caused by necrotizing retinitis.
 CiteULike  Connotea  Delicious  Digg  Facebook  Reddit  Technorati  Twitter
What's this?
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
|
Attenuation of Iodine 125 Radiation With Vitreous Substitutes in the Treatment of Uveal Melanoma
Oliver et al.
Arch Ophthalmol 2010;128:888-893.
ABSTRACT
| FULL TEXT
Outcomes of Complex Retinal Detachment Repair Using 1000- vs 5000-Centistoke Silicone Oil
Scott et al.
Arch Ophthalmol 2005;123:473-478.
ABSTRACT
| FULL TEXT
Elevated Intraocular Pressure and Hypotony Following Silicone Oil Retinal Tamponade for Complex Retinal Detachment: Incidence and Risk Factors
Henderer et al.
Arch Ophthalmol 1999;117:189-195.
ABSTRACT
| FULL TEXT
Guidelines for the Treatment of Cytomegalovirus Diseases in Patients With AIDS in the Era of Potent Antiretroviral Therapy: Recommendations of an International Panel
Whitley et al.
Arch Intern Med 1998;158:957-969.
ABSTRACT
| FULL TEXT
Surgical management of HIV related retinal detachment
CHARTERIS
Br J Ophthalmol 1997;81:177-178.
FULL TEXT
Retinal detachment in AIDS: long term results after repair with silicone oil
Irvine et al.
Br J Ophthalmol 1997;81:180-183.
ABSTRACT
| FULL TEXT
Acquired Immunodeficiency Syndrome and the Eye--1996
Jabs
Arch Ophthalmol 1996;114:863-866.
ABSTRACT
Cataract Extraction After Silicone Oil Repair of Retinal Detachments Due to Necrotizing Retinitis
Meldrum et al.
Arch Ophthalmol 1996;114:885-892.
ABSTRACT
The Use of Silicone Oil for HIV-Related Retinal Detachment
Blumenkranz
Arch Ophthalmol 1995;113:1366-1368.
ABSTRACT
|
