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Everton L. Arrindell, MD; James C. Wu, PhD; Mitchell D. Wolf, MD; Sumit Nanda, MD; Dennis P. Han, MD; Eric C. Wong, PhD; Gary W. Abrams, MD; William F. Mieler, MD; James S. Hyde, PhD

Arch Ophthalmol. 1995;113(1):96-102.

Abstract
Objective
To compare the effects of contact transscleral diode laser treatment and retinal cryotherapy on blood-retinal barrier integrity with the use of high-resolution magnetic resonance imaging techniques with constant infusion of gadolinium—diethylenetriaminepentaacetic acid (Gd-DTPA).

Methods
Transscleral diode laser photocoagulation and retinal cryotherapy were used to treat equivalent areas of the inferior retinal periphery of pigmented rabbits. Magnetic resonance imaging time-course studies with measurement of signal enhancements due to Gd-DTPA leak-age were conducted 2 and 15 days following treatment.

Results
Two days following treatment, cryotherapytreated eyes exhibited a mean (±SD) effective Gd-DTPA permeability coefficient of 4.6±0.8x10^–6 cm/s; in comparison, diode laser—treated eyes exhibited 1.6x1.4x10^–6 cm/s effective permeability. Significant decreases in the effective permeability were also noted 15 days after treatment in both groups.

Conclusions
Transscleral contact probe diode laser photocoagulation induces less disruption of the blood-retinal barrier than does conventional cryotherapy. In addition, the continuous infusion method of Gd-DTPA delivery is a reliable and easily interpretable alternative to the commonly used bolus injection approach.

Author Affiliations
From the Department of Ophthalmology (Drs Arrindell, Wolf, Nanda, Han, Abrams, and Mieler) and the Biophysics Research Institute (Drs Wu, Wong, Abrams, and Hyde), Medical College of Wisconsin, Milwaukee. Dr Arrindell is now with the Department of Ophthalmology, Meharry Medical College, Nashville, Tenn. The authors and institutions have no proprietary interest in the diode laser or MRI hardware used in these studies.

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