Crystallization on intraocular lens surfaces associated with the use of Healon GV
M. K. Jensen, A. S. Crandall, N. Mamalis and R. J. Olson
John A. Moran Eye Center, Department of Pharmacy Services, University of Utah Health Sciences Center, Salt Lake City.
OBJECTIVE: To describe a series of patients who had visually significant
crystalline deposits on their intraocular lenses during cataract surgery
with the use of Healon GV (a high concentration and high molecular-weight
hyaluronate sodium). METHODS: Patients were examined for crystalline
deposits on their intraocular lenses. These deposits were compared with
intraocular lens type, viscoelastic solutions, any other intraocular
substance used, type of surgery, and perioperative medications. RESULTS: In
the 11 patients with documented changes (six photographically), the only
consistent finding was the use of Healon GV. Furthermore, since we
discontinued the use of Healon GV, we have not seen a recurrence of these
deposits in more than 500 consecutive patients. The deposits could last a
long time (at least 6 months) if sequestered by the posterior capsule, and
they are believed to be visually significant at times (Snellen visual
acuity of 20/40 or worse). CONCLUSION: Healon GV use is associated with a
new clinical finding of crystalline deposits on intraocular lenses. These
deposits can be clinically significant.
