Visual field profile of optic neuritis. One-year follow-up in the Optic Neuritis Treatment Trial
J. L. Keltner, C. A. Johnson, J. O. Spurr and R. W. Beck
University of California-Davis.
PURPOSE: The purpose of this present study was to evaluate longitudinal
visual field information for 448 patients over their first year of
follow-up in the Optic Neuritis Treatment Trial. METHODS: We reviewed 6536
automated static visual fields performed on a visual field analyzer
(Humphrey Visual Field Analyzer) at nine visits within the 1-year period
for each of the patients. RESULTS: The median values of the mean deviations
for affected eyes were as follows: -22.88 dB at baseline, -1.94 dB at 6
months, and -1.62 dB at 1 year. At 6 months, 51% of affected eye visual
fields were normal, and at 1 year 55.9% were normal. Approximately two
thirds (68.8%) of the fellow eyes were classified as abnormal at baseline,
although the defects were generally slight. One third (33.2%) were abnormal
at 6 months, and approximately one third were still abnormal at 1 year.
More than 87% of those abnormal at 6 months and at 1 year had been abnormal
at baseline. Binocular analysis revealed that 13.2% of patients showed a
chiasmal or retrochiasmal type of field defect at least once during the
year (5.1% bitemporal; 8.9% homonymous). Of the patients who showed a
retrochiasmal visual field defect, 75.7% had an abnormal magnetic resonance
imaging scan at baseline compared with 46% of the rest of the patients in
the Optic Neuritis Treatment Trial (chi 2 = 10.73, df = 1, P < .002).
CONCLUSION: Over the first year of follow-up, the majority of patients with
visual field defects from acute optic neuritis returned to normal, as
measured by automated static perimetry. Many fields showed variation in the
pattern and location of the sensitivity loss. Chiasmal and retrochiasmal
defects occurred more commonly than previously reported.
The Optic Neuritis Treatment Trial: A Definitive Answer and Profound Impact With Unexpected Results
Volpe
Arch Ophthalmol 2008;126:996-999.
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Huang et al.
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Cheng et al.
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Kupersmith et al.
Neurology 2007;69:508-514.
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Menke et al.
IOVS 2005;46:3807-3811.
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Keltner et al.
Arch Ophthalmol 2003;121:643-650.
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Kupersmith et al.
Brain 2002;125:812-822.
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Rinalduzzi et al.
J. Neurol. Neurosurg. Psychiatry 2001;70:28-35.
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Hollander et al.
Br. J. Ophthalmol. 2000;84:1185-1190.
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Frequency Doubling Perimetry in Resolved Optic Neuritis
Fujimoto and Adachi-Usami
IOVS 2000;41:2558-2560.
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Practice parameter: The role of corticosteroids in the management of acute monosymptomatic optic neuritis: Report of the Quality Standards Subcommittee of the American Academy of Neurology
Kaufman et al.
Neurology 2000;54:2039-2044.
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Computerized color perimetry in multiple sclerosis
Accornero et al.
Mult Scler 1998;4:79-84.
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