You are seeing this message because your Web browser does not support basic Web standards. Find out more about why this message is appearing and what you can do to make your experience on this site better.


ABOUT ARCHIVES
Advanced Search

Welcome   | My Account | E-mail Alerts | Access Rights | Sign In


  Vol. 112 No. 3, March 1994 TABLE OF CONTENTS
  Archives
  •  Online Features
  ARTICLE
 This Article
 • Reply to article
 •Send to a friend
 • Save in My Folder
 •Save to citation manager
 •Permissions
 Citing Articles
 •Citation map
 •Citing articles on HighWire
 •Contact me when this article is cited
 Related Content
 •Similar articles in this journal

The eye in bone marrow transplantation. VI. Retinal complications

N. M. Coskuncan, D. A. Jabs, J. P. Dunn, J. A. Haller, W. R. Green, G. B. Vogelsang and G. W. Santos
Wilmer Ophthalmological Institute, Johns Hopkins University School of Medicine, Baltimore, MD.

OBJECTIVE: To evaluate the posterior segment ocular complications of patients undergoing bone marrow transplantation (BMT). DESIGN: Retrospective analysis. SETTING: Academic ophthalmology department at a tertiary care hospital with a BMT unit. PATIENTS: Patients undergoing BMT were seen by an ophthalmologist for clinical care and enrolled in a long-term follow-up study, during which they were seen 6 and 12 months after the transplantation and annually thereafter. RESULTS: Of 397 patients undergoing BMT, 51 (12.8%) developed posterior segment complications. Fourteen patients (3.5%) developed hemorrhagic complications with either intraretinal and/or vitreous hemorrhages and 17 patients (4.3%) developed cotton-wool spots in the fundus of both eyes. Eleven patients (2.8%) had bilateral optic disc edema, with eight cases attributed to the toxic effects of cyclosporine and three to other causes. Two patients (0.5%) developed serious retinal detachments. Eight patients (2.0%) developed infectious retinitis and/or endophthalmitis. Fungal infections with Candida or Aspergillus usually occurred within 120 days after BMT, while viral infections with herpes zoster or cytomegalovirus and parasitic infections with Toxoplasma occurred later. Intraocular lymphoma occurred in one patient (0.2%). CONCLUSION: Severe, potentially vision-threatening, posterior segment complications following BMT occur due to a variety of causes.

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Posterior segment complications of graft versus host disease after bone marrow transplantation
Strouthidis et al.
Br. J. Ophthalmol. 2003;87:1421-1423.
FULL TEXT  

Current Perspectives on Ophthalmic Mycoses
Thomas
Clin. Microbiol. Rev. 2003;16:730-797.
ABSTRACT | FULL TEXT  

Nonmalignant late effects after allogeneic stem cell transplantation
Socie et al.
Blood 2003;101:3373-3385.
FULL TEXT  

Unusual viral infections (progressive multifocal leukoencephalopathy and cytomegalovirus disease) after high-dose chemotherapy with autologous blood stem cell rescue and peritransplantation rituximab
Goldberg et al.
Blood 2002;99:1486-1488.
ABSTRACT | FULL TEXT  

Localization and Characterization of Calcineurin in Bovine Eye
Seitz et al.
IOVS 2002;43:15-21.
ABSTRACT | FULL TEXT  

Immune Recovery Vitritis in HIV Infection: Abstracts and Commentary
Dunn
JAMA 1998;280:185-186.
FULL TEXT  

A Novel Human Cytomegalovirus Glycoprotein, gpUS9, Which Promotes Cell-to-Cell Spread in Polarized Epithelial Cells, Colocalizes with the Cytoskeletal Proteins E-Cadherin and F-Actin
Maidji et al.
J. Virol. 1998;72:5717-5727.
ABSTRACT | FULL TEXT  





HOME | CURRENT ISSUE | PAST ISSUES | TOPIC COLLECTIONS | CME | SUBMIT | SUBSCRIBE | HELP
CONDITIONS OF USE | PRIVACY POLICY | CONTACT US | SITE MAP
 
© 1994 American Medical Association. All Rights Reserved.