 |
 |

The Eye in Bone Marrow TransplantationVI. Retinal Complications
Nezih M. Coskuncan, MD;
Douglas A. Jabs, MD;
J. P. Dunn, MD;
Julia A. Haller, MD;
W. Richard Green, MD;
Georgia B. Vogelsang, MD;
George W. Santos, MD
Arch Ophthalmol. 1994;112(3):372-379.
Abstract
 |  |
Objective To evaluate the posterior segment ocular complications of patients undergoing bone marrow transplantation (BMT).
Design Retrospective analysis.
Setting Academic ophthalmology department at a tertiary care hospital with a BMT unit.
Patients Patients undergoing BMT were seen by an ophthalmologist for clinical care and enrolled in a long-term follow-up study, during which they were seen 6 and 12 months after the transplantation and annually thereafter.
Results Of 397 patients undergoing BMT, 51 (12.8%) developed posterior segment complications. Fourteen patients (3.5%) developed hemorrhagic complications with either intraretinal and/or vitreous hemorrhages and 17 patients (4.3%) developed cotton-wool spots in the fundus of both eyes. Eleven patients (2.8%) had bilateral optic disc edema, with eight cases attributed to the toxic effects of cyclosporine and three to other causes. Two patients (0.5%) developed serous retinal detachments. Eight patients (2.0%) developed infectious retinitis and/or endophthalmitis. Fungal infections with Candida or Aspergillus usually occurred within 120 days after BMT, while viral infections with herpes zoster or cytomegalovirus and parasitic infections with Toxoplasma occurred later. Intraocular lymphoma occurred in one patient (0.2%).
Conclusion Severe, potentially vision-threatening, posterior segment complications following BMT occur due to a variety of causes.
Author Affiliations
From The Wilmer Ophthalmological Institute, the Department of Ophthalmology (Drs Coskuncan, Jabs, Dunn, Haller, and Green), and The Johns Hopkins Oncology Center (Drs Vogelsang and Santos), The Johns Hopkins University School of Medicine, Baltimore, Md.
CiteULike Connotea Del.icio.us Digg Reddit Technorati Twitter
What's this?
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
 |
Posterior segment complications of graft versus host disease after bone marrow transplantation
Strouthidis et al.
Br J Ophthalmol 2003;87:1421-1423.
FULL TEXT
Current Perspectives on Ophthalmic Mycoses
Thomas
Clin. Microbiol. Rev. 2003;16:730-797.
ABSTRACT
| FULL TEXT
Nonmalignant late effects after allogeneic stem cell transplantation
Socie et al.
Blood 2003;101:3373-3385.
FULL TEXT
Unusual viral infections (progressive multifocal leukoencephalopathy and cytomegalovirus disease) after high-dose chemotherapy with autologous blood stem cell rescue and peritransplantation rituximab
Goldberg et al.
Blood 2002;99:1486-1488.
ABSTRACT
| FULL TEXT
Localization and Characterization of Calcineurin in Bovine Eye
Seitz et al.
IOVS 2002;43:15-21.
ABSTRACT
| FULL TEXT
Immune Recovery Vitritis in HIV Infection: Abstracts and Commentary
Dunn
JAMA 1998;280:185-186.
FULL TEXT
A Novel Human Cytomegalovirus Glycoprotein, gpUS9, Which Promotes Cell-to-Cell Spread in Polarized Epithelial Cells, Colocalizes with the Cytoskeletal Proteins E-Cadherin and F-Actin
Maidji et al.
J. Virol. 1998;72:5717-5727.
ABSTRACT
| FULL TEXT
Screening for Cytomegalovirus Retinitis in Children
Baumal et al.
Arch Pediatr Adolesc Med 1996;150:1186-1192.
ABSTRACT
Pigmentary Irregularities and Optic Disc Edema After Heart Transplantation
Klaver et al.
Arch Ophthalmol 1995;113:1281-1285.
ABSTRACT
|