Oral imipramine and acute angle closure glaucoma

R. Ritch, T. Krupin, C. Henry and F. Kurata
Department of Ophthalmology, New York Eye and Ear Infirmary, NY.

OBJECTIVE: To document acute angle closure glaucoma temporally related to ingestion of oral imipramine hydrochloride. PATIENTS: Four patients with narrow angles received routinely prescribed doses of imipramine that triggered acute angle closure glaucoma. OUTCOME: Laser iridotomy was successful in all patients. CONCLUSIONS: Psychoactive drugs should be prescribed cautiously in patients with known narrow angles and should be monitored by an ophthalmologist.

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