This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Andrew F. Phillips, MD; Karin Szerenyi, MD; Mauro Campos, MD; Ronald R. Krueger, MD; Peter J. McDonnell, MD

Arch Ophthalmol. 1993;111(9):1273-1278.

Abstract
Objective
We investigated early mediators of inflammation following excimer laser ablation in a rabbit cornea model. The ability of topical anti-inflammatory agents to influence these responses was also examined.

Methods
Adult New Zealand white rabbits were subjected to photorefractive keratectomy with a 193-nm argon fluoride excimer laser. Prostaglandin E₂ and leukotriene B₄ levels were measured using an enzyme immunoassay, and leukocyte infiltration was determined histologically.

Results
Prostaglandin E₂ production was rapid and sustained, but we were unable to detect the presence of leukotriene B₄. Relative to control, postoperative topical diclofenac sodium treatment caused a significant decrease in prostaglandin E₂ levels and a significant increase in corneal leukocytes at 10 hours. Fluorometholone treatment did not significantly alter prostaglandin E₂ levels but markedly depressed leukocyte ingress.

Conclusions
Diclofenac reduces prostaglandin E₂ levels but not leukocyte infiltration in the cornea following photorefractive keratectomy and thus may be useful clinically to reduce postsurgical pain.

Author Affiliations
From the Doheny Eye Institute and the Department of Ophthalmology, University of Southern California School of Medicine, Los Angeles.

Footnotes
The authors and their family members have no financial or proprietary interest in any of the materials or methods described in this article.

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Topical Diclofenac Sodium Decreases the Substance P Content of Tears
Yamada et al.
Arch Ophthalmol 2002;120:51-54.
ABSTRACT | FULL TEXT  

Effect of Topical Ascorbic Acid on Free Radical Tissue Damage and Inflammatory Cell Influx in the Cornea After Excimer Laser Corneal Surgery
Kasetsuwan et al.
Arch Ophthalmol 1999;117:649-652.
ABSTRACT | FULL TEXT  

Oxygen free radical damage in the cornea after excimer laser therapy
Hayashi et al.
Br J Ophthalmol 1997;81:141-144.
ABSTRACT | FULL TEXT  

Effect of Diclofenac, Ketorolac, and Fluorometholone on Arachidonic Acid Metabolites Following Excimer Laser Corneal Surgery
Phillips et al.
Arch Ophthalmol 1996;114:1495-1498.
ABSTRACT  

Corneal Sensitivity and Burning Sensation: Comparing Topical Ketorolac and Diclofenac
Seitz et al.
Arch Ophthalmol 1996;114:921-924.
ABSTRACT  

Prevention of Keratocyte Loss After Corneal Deepithelialization in Rabbits
Nassaralla et al.
Arch Ophthalmol 1995;113:506-511.
ABSTRACT