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Evrydiki A. Bouzas, MD; Mark H. Scott, MD; George Mastorakos, MD; George P. Chrousos, MD; Muriel I. Kaiser-Kupfer, MD

Arch Ophthalmol. 1993;111(9):1229-1233.

Abstract
Objective
To examine the potential association of central serous chorioretinopathy with endogenous hypercortisolism (Cushing's syndrome).

Design
Ophthalmologic survey of consecutively admitted patients with endogenous Cushing's syndrome.

Setting
An eye clinic of a research center (National Eye Institute, Bethesda, Md).

Patients
Sixty consecutive patients with confirmed endogenous Cushing's syndrome.

Main Outcome Measures
Findings from complete ophthalmologic evaluation.

Results
Three (5%) of 60 patients had one or more episodes of appropriately documented central serous chorioretinopathy. In all cases, the episodes occurred during the period of hypercortisolism.

Conclusions
Central serous chorioretinopathy is an uncommon manifestation of endogenous Cushing's syndrome. Since central serous chorioretinopathy has been associated with other hypercortisolemic states, we suggest that glucocorticoids may play a role in the development of this disease.

Author Affiliations
From the Ophthalmic Genetics and Clinical Services Branch, National Eye Institute (Drs Bouzas, Scott, and Kaiser-Kupfer), and the Developmental Endocrinology Branch, National Institute of Child Health and Human Development (Drs Mastorakos and Chrousos), National Institutes of Health, Bethesda, Md.

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