You are seeing this message because your Web browser does not support basic Web standards. Find out more about why this message is appearing and what you can do to make your experience on this site better.


ABOUT ARCHIVES
Advanced Search

Welcome   | My Account | E-mail Alerts | Access Rights | Sign In


  Vol. 111 No. 9, September 1993 TABLE OF CONTENTS
  Archives
  •  Online Features
  Clinical Sciences
 This Article
 •References
 •Full text PDF
 • Reply to article
 •Send to a friend
 • Save in My Folder
 •Save to citation manager
 •Permissions
 Citing Articles
 •Citation map
 •Citing articles on HighWire
 •Contact me when this article is cited
 Related Content
 •Similar articles in this journal
 Social Bookmarking
  Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit Add to Technorati Add to Twitter What's this?

0.3% Ciprofloxacin Ophthalmic Ointment in the Treatment of Bacterial Keratitis

Kirk R. Wilhelmus, MD; Robert A. Hyndiuk, MD; Delmar R. Caldwell, MD; Robert L. Abshire, PhD; Alan T. Folkens, PhD; Louis B. Godio, PhD; Ciprofloxacin Ointment/Bacterial Keratitis Study Group

Arch Ophthalmol. 1993;111(9):1210-1218.


Abstract

Objective
To determine the efficacy and safety of topical 0.3% ciprofloxacin hydrochloride ophthalmic ointment in the treatment of bacterial keratitis.

Design
Prospective case series with a nonrandomized comparison of culture-positive, evaluable cases (ciprofloxacin ointment group) with culture-positive, concurrent patients (nonenrolled group) treated with conventional therapy.

Setting
Multicenter clinical study.

Patients
After informed consent was obtained, 253 eligible patients underwent corneal scrapings and received topical ciprofloxacin ointment; 145 (57%) had positive cultures and completed the follow-up schedule. Forty (70%) of 57 apparently eligible patients had culture-positive bacterial keratitis but were not enrolled in the ciprofloxacin ointment study during the same period.

Intervention
Ciprofloxacin ophthalmic ointment instilled every 1 to 2 hours for 2 days, then every 4 hours for 12 days.

Main Outcome Measures
Clinical evaluation of signs at 1, 3, 7, and 14 days of treatment and the overall condition classified as clinical success (cured or improved) or failure (unchanged or worse) during and after therapy.

Results
Clinical success with the initial treatment occurred in 135 patients (93%) in the ciprofloxacin ointment group and in 28 patients (70%) in the nonenrolled group. Of the 10 ciprofloxacin clinical failures, seven were staphylococcal; two, pneumococcal; and one, polybacterial. The 90% minimum inhibitory concentration of ciprofloxacin was 3 mg/L or less for corneal bacterial isolates. No serious adverse event attributable to ciprofloxacin ointment occurred, although 32 (13%) of 253 patients developed a transient white crystalline corneal precipitate shown with liquid chromatography in two cases to be ciprofloxacin.

Conclusion
Ciprofloxacin ophthalmic ointment is an effective and safe topical antimicrobial agent for the treatment of bacterial keratitis caused by susceptible microorganisms.



Author Affiliations

From the Cullen Eye Institute, Baylor College of Medicine, Houston, Tex (Dr Wilhelmus); the Eye Institute, Medical College of Wisconsin, Milwaukee (Dr Hyndiuk); the Department of Ophthalmology, Tulane Medical Center, New Orleans, La (Dr Caldwell); and Alcon Laboratories Inc, Fort Worth, Tex (Drs Abshire, Folkens, and Godio). Drs Abshire, Folkens, and Godio are employees of Alcon Laboratories Inc. The other authors have no proprietary interest in this work.



Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Comparison of virulence factors in Pseudomonas aeruginosa strains isolated from contact lens- and non-contact lens-related keratitis
Choy et al.
J Med Microbiol 2008;57:1539-1546.
ABSTRACT | FULL TEXT  

Topical ciprofloxacin can delay recovery from viral ocular surface infection
Patwardhan and Khan
JRSM 2005;98:274-275.
FULL TEXT  

Influence of Fluoroquinolone Susceptibility on the Therapeutic Response of Fluoroquinolone-Treated Bacterial Keratitis
Wilhelmus et al.
Arch Ophthalmol 2003;121:1229-1233.
ABSTRACT | FULL TEXT  

Overview: Initial antimicrobial therapy for microbial keratitis
Daniell
Br J Ophthalmol 2003;87:1172-1174.
FULL TEXT  

View 1: Corneal scraping and combination antibiotic therapy is indicated
Mills
Br J Ophthalmol 2003;87:1167-1169.
FULL TEXT  

Bacterial keratitis: predisposing factors, clinical and microbiological review of 300 cases
Bourcier et al.
Br J Ophthalmol 2003;87:834-838.
ABSTRACT | FULL TEXT  

In vitro antibiotic resistance in bacterial keratitis in London
Tuft and Matheson
Br J Ophthalmol 2000;84:687-691.
ABSTRACT | FULL TEXT  

Lysostaphin Treatment of Methicillin-Resistant Staphylococcus aureus Keratitis in the Rabbit
Dajcs et al.
IOVS 2000;41:1432-1437.
ABSTRACT | FULL TEXT  

Fluoroquinolone and fortified antibiotics for treating bacterial corneal ulcers
Gangopadhyay et al.
Br J Ophthalmol 2000;84:378-384.
ABSTRACT | FULL TEXT  

Risk factors for treatment outcome of suspected microbial keratitis
Morlet et al.
Br J Ophthalmol 1999;83:1027-1031.
ABSTRACT | FULL TEXT  

Scleral Buckle Infection With Ciprofloxacin-Resistant Pseudomonas aeruginosa
Chaudhry et al.
Arch Ophthalmol 1998;116:1251-1251.
FULL TEXT  

Efficacy of Ofloxacin vs Cefazolin and Tobramycin in the Therapy for Bacterial Keratitis: Report From the Bacterial Keratitis Study Research Group
O'Brien et al.
Arch Ophthalmol 1995;113:1257-1265.
ABSTRACT  





HOME | CURRENT ISSUE | PAST ISSUES | TOPIC COLLECTIONS | CME | SUBMIT | SUBSCRIBE | HELP
CONDITIONS OF USE | PRIVACY POLICY | CONTACT US | SITE MAP
 
© 1993 American Medical Association. All Rights Reserved.