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Pharmacologic Induction of Posterior Vitreous Detachment in the Rabbit
Thierry C. Verstraeten, MD;
Chris Chapman, MD;
Michael Hartzer, PhD;
Barry S. Winkler, PhD;
Michael T. Trese, MD;
George A. Williams, MD
Arch Ophthalmol. 1993;111(6):849-854.
Abstract
• Objective.
—To assay the proteolytic activity of plasmin on the vitreoretinal junction and to assess a potential facilitating effect on posterior vitreous detachment.
Methods.
—We injected 1 U of plasmin into the vitreous of rabbits. Some eyes underwent vitrectomy after plasmin injection. Electroretinography and electron microscopy were performed.
Results.
—In plasmin-treated eyes, electroretinography displayed a transient (3 days) decreased b-wave amplitude. Histologic examination demonstrated posterior vitreous detachment in eyes that received intravitreal plasmin followed by vitrectomy.
Conclusion.
—Plasmin may prove to be a useful biochemical adjunct to mechanical vitrectomy.
Author Affiliations
From the Eye Research Institute, Oakland University, Rochester, Mich (Drs Verstraeten, Chapman, Hartzer, Winkler, Trese, and Williams), and the Beaumont Eye Insitute, Royal Oak, Mich (Drs Verstraeten, Hartzer, Trese, and Williams). Dr Verstraeten is currently with the Retina Service, Eye and Ear Institute, University of Pittsburgh (Pa) School of Medicine.
Footnotes
Accepted for publication February 23, 1993.
Presented in part at the annual meeting of the Association for Research in Vision and Ophthalmology, Sarasota, Fla, May 4, 1992.
Reprint requests to Eye and Ear Institute, University of Pittsburgh School of Medicine, 203 Lothrop St, Pittsburgh, PA 15213 (Dr Verstraeten).
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