You are seeing this message because your Web browser does not support basic Web standards. Find out more about why this message is appearing and what you can do to make your experience on this site better.


ABOUT ARCHIVES
Advanced Search

Welcome   | My Account | E-mail Alerts | Access Rights | Sign In


  Vol. 111 No. 3, March 1993 TABLE OF CONTENTS
  Archives
  •  Online Features
  ARTICLE
 This Article
 • Reply to article
 •Send to a friend
 • Save in My Folder
 •Save to citation manager
 •Permissions
 Citing Articles
 •Citing articles on HighWire
 •Contact me when this article is cited
 Related Content
 •Similar articles in this journal

Mannitol, dextromethorphan, and catalase minimize ischemic damage to retinal pigment epithelium and retina

L. Y. Gupta and M. F. Marmor
Department of Ophthalmology, Stanford University School of Medicine, Calif. 94305-5308.

We studied the recovery of retinal pigment epithelium and retinal function after 80 minutes of pressure-induced ischemia in rabbits. Just before restoring circulation, we gave intravenous mannitol (an osmotic agent and free-radical scavenger), dextromethorphan (an N-methyl-D-aspartate receptor antagonist), or catalase (an antioxidant enzyme). Mannitol has not previously been shown to be protective for retinal or retinal pigment epithelial ischemia. At 24 hours after reperfusion, the electroretinogram b-wave was reduced to 37% of preischemic amplitude in untreated eyes, but it recovered to 67% to 80% after treatment with all three agents. The c-wave was replaced by a negative slow PIII response in control eyes and in seven of 12 catalase-treated eyes, but it recovered by 58% to 82% in the remaining catalase-treated eyes and all the mannitol- and dextromethorphan-treated eyes. Histologic examination confirmed that retinal pigment epithelium as well as retina had been damaged by the ischemia. The effects of mannitol seem of special interest, since the drug has a dual mechanism of action and is clinically available.

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Retinal light damage: structural and functional effects of the antioxidant glutathione peroxidase-1.
Gosbell et al.
IOVS 2006;47:2613-2622.
ABSTRACT | FULL TEXT  

Hypoglycemia Induces General Neuronal Death, Whereas Hypoxia and Glutamate Transport Blockade Lead to Selective Retinal Ganglion Cell Death In Vitro
Luo et al.
IOVS 2001;42:2695-2705.
ABSTRACT | FULL TEXT  

A hypothesis to explain ganglion cell death caused by vascular insults at the optic nerve head: possible implication for the treatment of glaucoma
OSBORNE et al.
Br. J. Ophthalmol. 2001;85:1252-1259.
FULL TEXT  

Oral vitamins C and E as additional treatment in patients with acute anterior uveitis: a randomised double masked study in 145 patients
van Rooij et al.
Br. J. Ophthalmol. 1999;83:1277-1282.
ABSTRACT | FULL TEXT  





HOME | CURRENT ISSUE | PAST ISSUES | TOPIC COLLECTIONS | CME | SUBMIT | SUBSCRIBE | HELP
CONDITIONS OF USE | PRIVACY POLICY | CONTACT US | SITE MAP
 
© 1993 American Medical Association. All Rights Reserved.