Multicenter trial of cryotherapy for retinopathy of prematurity. 3 1/2-year outcome--structure and function. Cryotherapy for Retinopathy of Prematurity Cooperative Group

Cryotherapy for Retinopathy of Prematurity Cooperative Group Reports from the 3- and 12-month follow-up examinations in the Multicenter Cryotherapy for Retinopathy of Prematurity trial indicated a beneficial effect of cryotherapy in the treatment of severe retinopathy of prematurity. This report provides results from the 3 1/2-year follow-up examination on 92% of the 256 survivors from the original cohort of 291 infants in the randomized trial. Functional outcome was evaluated by masked assessment of letter acuity using the HOTV crowded letter test and grating acuity using the Teller Acuity Card procedure. Structural outcome was evaluated by physician's assessment of retinopathy of prematurity residua in the posterior pole. All three outcome measures showed a reduction in unfavorable outcomes in treated vs control eyes: 46.6% vs 57.5% (P < .01) for letter acuity, 52.4% vs 65.6% (P < .001) for grating acuity, and 26.1% vs 45.4% (P < .001) for posterior pole status. These results support the long-term efficacy and safety of cryotherapy in the treatment of severe retinopathy of prematurity.

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Evaluating the Cryotherapy for Retinopathy of Prematurity Study (CRYO-ROP)
Mills
Arch Ophthalmol 2007;125:1276-1281.
FULL TEXT  

Pharmacologic and Genetic Manipulation of MMP-2 and -9 Affects Retinal Neovascularization in Rodent Models of OIR
Barnett et al.
IOVS 2007;48:907-915.
ABSTRACT | FULL TEXT  

Long term functional and structural outcomes of laser therapy for retinopathy of prematurity
McLoone et al.
Br. J. Ophthalmol. 2006;90:754-759.
ABSTRACT | FULL TEXT  

Near Confluent Laser Photocoagulation for the Treatment of Threshold Retinopathy of Prematurity
Rezai et al.
Arch Ophthalmol 2005;123:621-626.
ABSTRACT | FULL TEXT  

15-Year Outcomes Following Threshold Retinopathy of Prematurity: Final Results From the Multicenter Trial of Cryotherapy for Retinopathy of Prematurity
Cryotherapy for Retinopathy of Prematurity Coopera
Arch Ophthalmol 2005;123:311-318.
ABSTRACT | FULL TEXT  

Treated threshold stage 3 versus spontaneously regressed subthreshold stage 3 retinopathy of prematurity: a study of motility, refractive, and anatomical outcomes at 6 months and 36 months
Sahni et al.
Br. J. Ophthalmol. 2005;89:154-159.
ABSTRACT | FULL TEXT  

Variations in the morphology of retinopathy of prematurity in extremely low birthweight infants
Schulenburg and Tsanaktsidis
Br. J. Ophthalmol. 2004;88:1500-1503.
ABSTRACT | FULL TEXT  

Educational and Social Competencies at 8 Years in Children With Threshold Retinopathy of Prematurity in the CRYO-ROP Multicenter Study
Msall et al.
Pediatrics 2004;113:790-799.
ABSTRACT | FULL TEXT  

Multicenter Trial of Cryotherapy for Retinopathy of Prematurity: Natural History ROP: Ocular Outcome at 51/2 Years in Premature Infants With Birth Weights Less Than 1251 g
Editorial Committee; for Cryotherapy for Retinopat
Arch Ophthalmol 2002;120:595-599.
ABSTRACT | FULL TEXT  

Screening Examination of Premature Infants for Retinopathy of Prematurity
Section on Ophthalmology
Pediatrics 2001;108:809-811.
ABSTRACT | FULL TEXT  

Multicenter Trial of Cryotherapy for Retinopathy of Prematurity: Ophthalmological Outcomes at 10 Years
Cryotherapy for Retinopathy of Prematurity Coopera
Arch Ophthalmol 2001;119:1110-1118.
ABSTRACT | FULL TEXT  

Effect of Retinal Ablative Therapy for Threshold Retinopathy of Prematurity: Results of Goldmann Perimetry at the Age of 10 Years
Cryotherapy for Retinopathy of Prematurity Coopera
Arch Ophthalmol 2001;119:1120-1125.
ABSTRACT | FULL TEXT  

Contrast Sensitivity at Age 10 Years in Children Who Had Threshold Retinopathy of Prematurity
Cryotherapy for Retinopathy of Prematurity Coopera
Arch Ophthalmol 2001;119:1129-1133.
ABSTRACT | FULL TEXT  

Ten-Year Follow-up From the CRYO-ROP Study
Tasman
Arch Ophthalmol 2001;119:1200-1201.
FULL TEXT  

The Effect of an Angiostatic Steroid on Neovascularization in a Rat Model of Retinopathy of Prematurity
Penn et al.
IOVS 2001;42:283-290.
ABSTRACT | FULL TEXT  

Diode laser treatment of posterior retinopathy of prematurity
Axer-Siegel et al.
Br. J. Ophthalmol. 2000;84:1383-1386.
ABSTRACT | FULL TEXT  

Severity of Neonatal Retinopathy of Prematurity Is Predictive of Neurodevelopmental Functional Outcome at Age 5.5 Years
Msall et al.
Pediatrics 2000;106:998-1005.
ABSTRACT | FULL TEXT  

Cost-Effectiveness of Treatment for Threshold Retinopathy of Prematurity
Brown et al.
Pediatrics 1999;104:47e-47.
ABSTRACT | FULL TEXT  

Ophthalmological follow up of preterm infants: a population based, prospective study of visual acuity and strabismus
Holmström et al.
Br. J. Ophthalmol. 1999;83:143-150.
ABSTRACT | FULL TEXT  

Longer term visual outcome of eyes with retinopathy of prematurity treated with cryotherapy or diode laser
O'Keefe et al.
Br. J. Ophthalmol. 1998;82:1246-1248.
ABSTRACT | FULL TEXT  

Three year visual outcome for treated stage 3 retinopathy of prematurity: cryotherapy versus laser
Pearce et al.
Br. J. Ophthalmol. 1998;82:1254-1259.
ABSTRACT | FULL TEXT  

Ophthalmological long term follow up of preterm infants: a population based, prospective study of the refraction and its development
Holmström et al.
Br. J. Ophthalmol. 1998;82:1265-1271.
ABSTRACT | FULL TEXT  

Timing of Initial Screening Examinations for Retinopathy of Prematurity
Hutchinson et al.
Arch Ophthalmol 1998;116:608-612.
ABSTRACT | FULL TEXT  

Myopia of prematurity
PHELPS; et al.
Br. J. Ophthalmol. 1997;81:1021-1021.
FULL TEXT  

Myopia of prematurity: nature, nurture, or disease?
FIELDER and QUINN
Br. J. Ophthalmol. 1997;81:2-3.
FULL TEXT  

Cryotherapy and laser treatment for acute retinopathy of prematurity: refractive outcomes, a longitudinal study
Laws et al.
Br. J. Ophthalmol. 1997;81:12-15.
ABSTRACT | FULL TEXT  

School-Age Outcomes in Children with Birth Weights under 750 g
Hack et al.
NEJM 1994;331:753-759.
ABSTRACT | FULL TEXT