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Paul T. Finger, MD; Paul P. Svitra, MD; Steven A. McCormick, MD; Adolph Presser, MS

Arch Ophthalmol. 1993;111(2):254-258.

Abstract
• Microwaves were used to induce chorioretinal scar formation in normal rabbit eyes. We have developed a directional 6.8-gigahertz microwave applicator with a rectangular aperture. It was designed to mimic the shape and function of a T-shaped scleral depressor. For treatment, the applicator was placed on the conjunctiva over the sclera. Then, indentation was used to visualize probe placement during indirect ophthalmoscopy. Thermocouple-controlled heating was initiated such that conjunctival temperatures in a range of 51°C to 65°C were induced for 10 seconds per treatment. We found that treatment at temperatures of 51°C or 52°C for 10 seconds produced circular areas of acute retinal whitening. From these microwave-induced lesions, there evolved chorioretinal attenuation with and without evidence of retinal pigment epithelial hyperplasia. No evidence of scleral damage was noted at these thermal doses.

Author Affiliations
From the Department of Ophthalmology, North Shore University Hospital-Cornell University Medical College, Manhasset, NY (Drs Finger and Svitra); the Departments of Ophthalmology (Dr Finger) and Pathology (Dr McCormick), The New York (NY) Eye and Ear Infirmary; MMTC Inc, Princeton, NJ (Mr Presser); and the Department of Ophthalmology, Cornell University Medical College, New York, NY (Drs Finger and Svitra). Dr Finger has submitted a patent covering the design and use of the device and procedure described in this study. Drs Svitra and McCormick have no proprietary interest in the materials and/or methods described in this study. Mr Presser was and is currently employed by and owns one share of MMTC Inc.

Footnotes
Accepted for publication July 15, 1992.

Presented in part at the Annual Meeting of the Association for Research in Vision and Ophthalmology, Sarasota, Fla, May 8, 1992.

Reprint requests to Division of Ocular Tumor and Orbital Disease, Department of Ophthalmology, North Shore University Hospital-Cornell University Medical College, 300 Community Dr, Manhasset, NY 11030 (Dr Finger).

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