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Stephen J. Saxe, MD; Hans E. Grossniklaus, MD; Pedro F. Lopez, MD; H. Michael Lambert, MD; Paul Sternberg, Jr, MD; Nancy L'Hernault, MA

Arch Ophthalmol. 1993;111(1):88-95.

Abstract
• We evaluated the ultrastructural features of seven surgically excised submacular neovascular membranes from seven patients with the ocular histoplasmosis syndrome. Excised neovascular membranes were composed of fibrovascular tissue interposed between Bruch's membrane and the retinal pigment epithelium. Cellular components present in the membranes included, in decreasing order of frequency, retinal pigment epithelium, vascular endothelium, photoreceptor cells, macrophages, erythrocytes, ghost erythrocytes, fibrocytes, myofibroblasts, glial cells, smooth-muscle cells, and lymphocytes. Extracellular constituents of the neovascular membranes included 20 to 25-nm collagen fibrils, fibrin, 10-nm collagen fibrils, and fragments of Bruch's membrane and choroid. Our findings are consistent with the concept that subretinal neovascular membranes in the ocular histoplasmosis syndrome represent a nonspecific healing response to a local stimulus or injury.

Author Affiliations
From the Departments of Ophthalmology (Drs Saxe, Grossniklaus, Lopez, Lambert, and Sternberg and Ms L'Hernault) and Pathology (Dr Grossniklaus), Emory University, Atlanta, Ga. Dr Lopez was a 1990-1992 Heed-Knapp Fellow. Dr Lopez is now with the Dohney Eye Insitute, Los Angeles, Calif. Dr Lambert is now with the Cullen Eye Institute, Houston, Tex.

Footnotes
Accepted for publication August 11, 1992.

Reprint requests to the L. F. Montgomery Ophthalmic Pathology Laboratory, Room 1603, Emory Eye Center, 1327 Clifton Rd NE, Atlanta, GA 30322 (Dr Grossniklaus).

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