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Ofloxacin vs Tobramycin for the Treatment of External Ocular Infection
Arlene Gwon, MD;
for the Ofloxacin Study Group II
Arch Ophthalmol. 1992;110(9):1234-1237.
Abstract
• A multicenter, double-masked, randomized clinical investigation was conducted comparing 0.3% ofloxacin and 0.3% tobramycin for topical treatment of external ocular infection. One drop ( 1.35 µg) of either test solution was instilled six times daily for 2 days and thereafter four times daily for the next 8 days. At the day 3 to 5 follow-up examination, the severity of signs and symptoms based on a clinical summary score of 10 key variables was reduced from baseline values significantly (P<0.5) more with ofloxacin (–6.4±4.37; mean±SD) than with tobramycin (–4.78±3.13); by day 11, the difference between the groups was no longer significant. At days 3 to 5 and day 11 examinations, clinical, microbiologic, and overall improvement rates were similar, with no significant differences seen between the groups. Ofloxacin was found as effective, safe, and comfortable as tobramycin in patients with external ocular infection and may provide earlier symptom relief.
Author Affiliations
From Allergan Pharmaceuticals, Irvine, Calif.
Footnotes
Accepted for publication February 20, 1992.
Presented as a scientific exhibit at the annual meeting of the American Academy of Ophthalmology, October 28 to November 2,1989, New Orleans, La.
Reprint requests to Allergan Pharmaceuticals, 2525 Dupont Dr, Irvine, CA 92713-9534 (Dr Gwon).
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