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Charles A. Wilson, MD; Bruce A. Berkowitz, PhD; Yukihiro Sato, MD; Noburo Ando, MD; James T. Handa, MD; Eugene de Juan, Jr, MD

Arch Ophthalmol. 1992;110(8):1155-1159.

Abstract
• The effect of corticosteroid treatment on blood-retinal barrier breakdown caused by argon-laser panretinal photocoagulation was evaluated in the rabbit eye. One day before photocoagulation, eyes were given either a sub-Tenon (20-mg) or intravitreal (2-mg) injection of triamcinolone acetonide. The severity of blood-retinal barrier breakdown was measured after photocoagulation using rapid sequential magnetic resonance imaging follow-ing intravenous administration of gadolinium diethylenetriaminepentaacetic acid. Leakage of gadolinium diethylenetriaminepentaacetic acid into the vitreous space was significantly lower in eyes that received intravitreal triamcinolone acetonide than in control eyes (P=.007); however, sub-Tenon triamcinolone acetonide produced no significant reduction in leak-age (P=.65) compared with controls. Fluorescein angiography supported the magnetic resonance imaging findings. We conclude that retinal photocoagulation in the rabbit eye produces blood-retinal barrier breakdown that is partially amenable to corticosteroid treatment.

Author Affiliations
From the Department of Ophthalmology, Duke University Medical Center, Durham, NC (Drs Wilson, Sato, Ando, Handa, and de Juan), and National Institutes of Environmental Health Sciences, Research Triangle Park, NC (Dr Berkowitz). Dr Sato is on leave from the Department of Ophthalmology, Nihon University, Tokyo, Japan; Dr Ando is on leave from the Department of Ophthalmology, Niigata (Japan) University; and Drs Wilson and Berkowitz are now with the Department of Ophthalmology, Southwestern Medical School, Dallas, Tex.

Footnotes
Accepted for publication January 28, 1992.

Reprint requests to Duke University Medical Center, Box 3802, Durham, NC 27710 (Dr de Juan).

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