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  Vol. 110 No. 8, August 1992 TABLE OF CONTENTS
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Detection of Varicella Zoster Virus DNA and Viral Antigen in the Late Stage of Bilateral Acute Retinal Necrosis Syndrome

Volker Rummelt, MD; Hartmut Wenkel; Carmen Rummelt; Gerhard Jahn, MD; Hans J. Meyer, MD; Gottfried O. H. Naumann, MD

Arch Ophthalmol. 1992;110(8):1132-1136.


Abstract



• We describe the clinicopathologic and virologic findings in the right, blind eye of an immunocompetent 61-year-old woman. The eye was enucleated 32 months after the clinical onset of a bilateral acute retinal necrosis syndrome. Histopathologic study showed a diffuse, full-thickness, necrotizing retinitis with replacement of sensory retinal structures by glial tissue, occlusive retinal arteritis, granulomatous choroiditis, and optic neuritis with ischemic optic atrophy. Varicella zoster virus could be identified as the causative agent by DNA in situ hybridization and by immunohistochemical stains in mononuclear cells with eosinophilic intracytoplasmic inclusions. Virus was detected only within the choroid and the choriocapillaris. We conclude that these histopathologic and virologic features are consistent with a "burned-out phase" of a varicella zoster virus—induced acute retinal necrosis syndrome.



Author Affiliations



From the Department of Ophthalmology (Drs Rummelt and Naumann, Mr Wenkel, and Ms Rummelt) and Institute of Clinical and Molecular Virology (Dr Jahn), University of Erlangen-Nürnberg, Erlangen, and the Department of Ophthalmology, Marienhospital Osnabrück, Osnabrück (Dr Meyer), Federal Republic of Germany.


Footnotes



Accepted for publication February 25, 1992.

Presented in part at the Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO), Sarasota, Fla, April 30,1990, and the European Ophthalmic Pathology Society, Coimbra, Portugal, June 5, 1990.

Reprint requests to Department of Ophthalmology, University of Erlangen-Nürnberg, Schwabachanlage 6, D-8520 Erlangen, Germany (Dr Rummelt).



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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Immune Choroiditis Following Acute Retinal Necrosis
Basu
Arch Ophthalmol 2011;129:816-816.
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Immune Choroiditis Following Contralateral Acute Retinal Necrosis
Wong et al.
Arch Ophthalmol 2010;128:1364-1366.
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Detection of Varicella-zoster Virus DNA in Keratectomy Specimens by Use of the Polymerase Chain Reaction
Mietz et al.
Arch Ophthalmol 1997;115:590-594.
ABSTRACT  





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