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Diverse Appearances of Uveal Malignant Melanomas

Philip A. Bloom, FCOphth; John D. Ferris, MB; David A. H. Laidlaw, FCOphth; Paul R. Goddard, FRCR

Arch Ophthalmol. 1992;110(8):1105-1111.

Abstract
• Fifteen patients with uveal malignant melanomas were studied by magnetic resonance imaging. The magnetic resonance imaging appearances varied from those that have been reported previously to be characteristic of these tumors. In our series, malignant melanomas were of high signal on the T₁ sequence and of variable but usually also of high signal on the T₂ and Short Tau/nversion Recovery (STIR) sequences, a signal combination rarely described before. We postulate that magnetic resonance imaging appearances may be dependent on variations in histologic factors and on the type and field strength of the scanner used. It is widely believed that the paramagnetic melanin in malignant melanomas gives these tumors characteristic magnetic resonance imaging appearances, but our finding of diverse magnetic resonance imaging appearances for proved malignant melanomas suggests that this may not always be the case. We advise caution in diagnosing malignant melanomas from magnetic resonance imaging appearances alone.

Author Affiliations
From the Department of Ophthalmology, Bristol (England) Eye Hospital (Drs Bloom, Ferris, and Laidlaw), and the Bristol Magnetic Resonance Imaging Centre, Frenchay Hospital (Dr Goddard). Dr Bloom is now with Moorfields Eye Hospital, London, England.

Footnotes
Accepted for publication February 13, 1992.

Reprint requests to Moorfields Eye Hospital, 162 City Rd, London, England EC1 2PD (Dr Bloom).

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