Expression of cell adhesion molecules in posterior uveitis
S. M. Whitcup, C. C. Chan, Q. Li and R. B. Nussenblatt
Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, Md. 20892.
Cells in the eye express surface molecules that direct leukocyte migration
during ocular inflammation. We studied the expression of intercellular
adhesion molecule-1, lymphocyte function-associated antigen-1, and
endothelial leukocyte adhesion molecule-1 in six enucleated eyes from
patients with uveitis and in seven normal control eyes. Lymphocyte
function-associated antigen-1 was expressed on infiltrating lymphocytes and
intercellular adhesion molecule-1 was expressed on endothelial cells of
retinal and choroidal blood vessels and the retinal pigment epithelium in
all uveitic eyes, but in none of the normal control eyes. Ocular
inflammatory cells stained strongly positive for tumor necrosis factor
alpha in all eyes with uveitis, but four of six uveitic eyes showed mild
staining for tumor necrosis factor beta and interferon gamma. Cell adhesion
molecules are expressed in eyes with posterior uveitis and may be regulated
by cytokines such as tumor necrosis factor alpha.
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