Cataract extraction after proton beam irradiation for malignant melanoma of the eye
E. S. Gragoudas, K. M. Egan, P. G. Arrigg, J. M. Seddon, R. J. Glynn and J. E. Munzenrider
Department of Ophthalmology, Harvard Medical School, Boston, MA.
We evaluated visual outcome and risk of metastases in patients who
underwent cataract extraction after protonbeam irradiation of a uveal
melanoma. A total of 84 patients underwent cataract extraction between 2
months and 11 years after irradiation. One year after cataract extraction,
approximately half of the patients had visual acuity of 20/100 or better,
and approximately one third had an acuity of 20/40 or better. Larger tumor
size was highly correlated with poor visual outcome 1 year after
extraction. Six patients underwent enucleation after cataract removal, five
due to blind, painful eyes and one due to continued growth of a previously
undiagnosed ring melanoma. The rate of metastases was not higher among
patients who underwent cataract extraction (adjusted rate ratio, 0.83).
Results suggest that cataract extraction offers improvement of vision in
selected eyes previously irradiated for a uveal melanoma, without adding to
the risk of metastases among patients undergoing the procedure.
