 |
 |

Pseudoexfoliative Fibrillopathy in Visceral Organs of a Patient With Pseudoexfoliation Syndrome
Barbara W. Streeten, MD;
Zong-Yi Li, MD;
Robert N. Wallace, BS;
Ralph C. Eagle, Jr, MD;
Albert A. Keshgegian, MD, PhD
Arch Ophthalmol. 1992;110(12):1757-1762.
Abstract
 |  |
Evidence is increasing that pseudoexfoliative material develops in widespread areas of skin and parabulbar tissues as well as intraocularly. To determine whether this process is even more diffusely distributed, ultrastructural examination was performed on visceral and ocular tissues of a patient with longstanding glaucoma found to have bilateral ocular pseudoexfoliation at autopsy. Aggregates consistent with pseudoexfoliative material were present in the lung, heart, liver, and gallbladder, in addition to the classic intraocular sites. The aggregates were in the fibrovascular septa and stroma of these organs, most frequently adjacent to elastic and oxytalan fibers. They stained positively for elastin and human amyloid P protein, like the ocular sites, in preliminary immunologic testing. Rare atypical aggregates were seen in one of the four control patients. These findings suggest that pseudoexfoliation is a systemic process involving abnormal matrix synthesis, particularly as related to elastic tissue components.
Author Affiliations
From the Departments of Ophthalmology and Pathology, State University of New York Health Science Center at Syracuse (Drs Streeten and Li and Mr Wallace); Wills Eye Hospital, Philadelphia, Pa (Dr Eagle); and Bryn Mawr (Pa) Hospital (Dr Keshgegian).
Footnotes
Accepted for publication September 15, 1992.
Reprint requests to Department of Pathology, Weiskotten Hall, State University of New York Health Science Center, 766 Irving Ave, Syracuse, NY 13210 (Dr Streeten).
CiteULike Connotea Del.icio.us Digg Reddit Technorati Twitter
What's this?
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
 |
Prevalence of exfoliation syndrome in central Sri Lanka: the Kandy Eye Study
Rudkin et al.
Br J Ophthalmol 2008;92:1595-1598.
ABSTRACT
| FULL TEXT
Exfoliation Syndrome: Beyond Glaucoma
Ritch
Arch Ophthalmol 2008;126:859-861.
FULL TEXT
Increase of carotid artery stiffness and decrease of baroreflex sensitivity in exfoliation syndrome and glaucoma
Visontai et al.
Br J Ophthalmol 2006;90:563-567.
ABSTRACT
| FULL TEXT
Differential Gene Expression in Pseudoexfoliation Syndrome
Zenkel et al.
IOVS 2005;46:3742-3752.
ABSTRACT
| FULL TEXT
Unilateral or Asymmetric Pseudoexfoliation Syndrome?: An Ultrastructural Study
Hammer et al.
Arch Ophthalmol 2001;119:1023-1031.
ABSTRACT
| FULL TEXT
Pseudoexfoliation syndrome in Icelandic families
Allingham et al.
Br J Ophthalmol 2001;85:702-707.
ABSTRACT
| FULL TEXT
Exfoliation Syndrome in a 17-Year-Old Girl
Konstas et al.
Arch Ophthalmol 1997;115:1063-1067.
ABSTRACT
HNK-1 Epitope in the Lens--Ciliary Zonular Region in Normal and Pseudoexfoliative Eyes: Immunohistochemistry and Ultrastructure
Qi et al.
Arch Ophthalmol 1997;115:637-644.
ABSTRACT
Immunoreactivity of Exfoliation Material for the Cell Adhesion--Related HNK-1 Carbohydrate Epitope
Uusitalo et al.
Arch Ophthalmol 1993;111:1419-1423.
ABSTRACT
|