You are seeing this message because your Web browser does not support basic Web standards. Find out more about why this message is appearing and what you can do to make your experience on this site better.


ABOUT ARCHIVES
Advanced Search

Welcome   | My Account | E-mail Alerts | Access Rights | Sign In


  Vol. 110 No. 12, December 1992 TABLE OF CONTENTS
  Archives
  •  Online Features
  ARTICLE
 This Article
 • Reply to article
 •Send to a friend
 • Save in My Folder
 •Save to citation manager
 •Permissions
 Citing Articles
 •Citation map
 •Citing articles on HighWire
 •Contact me when this article is cited
 Related Content
 •Similar articles in this journal

Pseudoexfoliative fibrillopathy in visceral organs of a patient with pseudoexfoliation syndrome

B. W. Streeten, Z. Y. Li, R. N. Wallace, R. C. Eagle Jr and A. A. Keshgegian
Department of Ophthalmology, State University of New York Health Science Center, Syracuse 13210.

Evidence is increasing that pseudoexfoliative material develops in widespread areas of skin and parabulbar tissues as well as intraocularly. To determine whether this process is even more diffusely distributed, ultrastructural examination was performed on visceral and ocular tissues of a patient with long-standing glaucoma found to have bilateral ocular pseudoexfoliation at autopsy. Aggregates consistent with pseudoexfoliative material were present in the lung, heart, liver, and gallbladder, in addition to the classic intraocular sites. The aggregates were in the fibrovascular septa and stroma of these organs, most frequently adjacent to elastic and oxytalan fibers. They stained positively for elastin and human amyloid P protein, like the ocular sites, in preliminary immunologic testing. Rare atypical aggregates were seen in one of the four control patients. These findings suggest that pseudoexfoliation is a systemic process involving abnormal matrix synthesis, particularly as related to elastic tissue components.

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Exfoliation Syndrome: Beyond Glaucoma
Ritch
Arch Ophthalmol 2008;126:859-861.
FULL TEXT  

Increase of carotid artery stiffness and decrease of baroreflex sensitivity in exfoliation syndrome and glaucoma
Visontai et al.
Br. J. Ophthalmol. 2006;90:563-567.
ABSTRACT | FULL TEXT  

Differential Gene Expression in Pseudoexfoliation Syndrome
Zenkel et al.
IOVS 2005;46:3742-3752.
ABSTRACT | FULL TEXT  

Unilateral or Asymmetric Pseudoexfoliation Syndrome?: An Ultrastructural Study
Hammer et al.
Arch Ophthalmol 2001;119:1023-1031.
ABSTRACT | FULL TEXT  

Pseudoexfoliation syndrome in Icelandic families
Allingham et al.
Br. J. Ophthalmol. 2001;85:702-707.
ABSTRACT | FULL TEXT  





HOME | CURRENT ISSUE | PAST ISSUES | TOPIC COLLECTIONS | CME | SUBMIT | SUBSCRIBE | HELP
CONDITIONS OF USE | PRIVACY POLICY | CONTACT US | SITE MAP
 
© 1992 American Medical Association. All Rights Reserved.