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MK-507 (L-671,152), a Topically Active Carbonic Anhydrase Inhibitor, Reduces Aqueous Humor Production in Monkeys
Rong-Fang Wang, MD;
Janet B. Serle, MD;
Steven M. Podos, MD;
Michael F. Sugrue, PhD
Arch Ophthalmol. 1991;109(9):1297-1299.
Abstract
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• An investigation was carried out to determine the mechanism by which MK-507 (L-671,152), a water-soluble inhibitor of human carbonic anhydrase II in vitro, reduces intraocular pressure when applied topically to monkey eyes. Intraocular pressure, tonographically measured outflow facility, and fluorophotometrically determined aqueous humor flow were measured before and after therapy in eight normal cynomolgus monkeys. Fifty microliters of 2% MK-507 was instilled in one eye and diluent in the contralateral eye. Baseline values for intraocular pressure, outflow facility, and aqueous humor flow were similar in the drug-treated and diluent-treated control eyes. After therapy, intraocular pressure was significantly (P<.05) reduced from 1 to 7 hours (eg, 14.0±1.0 and 15.9±0.9 mm Hg [mean±SEM], treated and control eyes, respectively, at 3 hours). Outflow facility was not significantly (P>.40) changed at 3 hours, and aqueous humor flow measured over 5 hours was significantly (P<.05) reduced (38%) in treated (0.9±0.1 µL/min) as compared with control eyes (1.5±0.1 µL/min). The results suggest that MK-507 reduces intraocular pressure by decreasing aqueous humor production.
Author Affiliations
From the Department of Ophthalmology, Mount Sinai School of Medicine, New York, NY (Drs Wang, Serle, and Podos); and Merck Sharp & Dohme Research Laboratories, West Point, Pa (Dr Sugrue).
Footnotes
Accepted for publication May 13, 1991.
Reprint requests to Mount Sinai Medical Center, One Gustave L. Levy PI, New York, NY 10029 (Dr Serle).
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