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Results of a Randomized Clinical Trial

Gabriel Coscas, MD; Gisèle Soubrane, MD; Christiane Ramahefasolo, MD; Christine Fardeau, MD

Arch Ophthalmol. 1991;109(9):1258-1265.

Abstract
• In a controlled clinical trial, 160 eyes underwent "perifoveal" laser photocoagulation. All patients had age-related macular degeneration and subfoveal neovascularization (0.5 to 2.5 disc diameters), without detectable fibrous tissue, and visual acuity from 20/100 to 20/1000. At least 1 year of follow-up has been completed in 127 eyes. Visual acuity was maintained or improved in 12 (20.3%) of 59 untreated eyes vs 28 (41.1%) of 68 treated eyes (P=.04). Reading visual acuity (J4) with the use of low-vision aids was retained in 28 untreated eyes (47.4%) vs 50 treated eyes (73.5%) (P<.01). Automated static perimetry showed an increased scotomatous area and/or depth with eccentric fixation in all but four patients. A flat atrophic scar was achieved in 53 of 68 treated eyes. Statistical analysis indicated that perifoveal photocoagulation has been effective in the short-term preservation of visual acuity.

Author Affiliations
From the Department of Ophthalmology of Créteil, University of Paris-XII, Créteil, France.

Footnotes
Accepted for publication June 10, 1991.

Presented in part at the Second International Congress on Laser Technologies, Lugano, Switzerland, May 25, 1989.

Reprint requests to the Hopital de Créteil, Ave Verdun, 40, Créteil, 94010, France (Dr Coscas).

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