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Mizuo Phenomenon in X-linked RetinoschisisPathogenesis of the Mizuo Phenomenon
Paul T. V. M. de Jong, MD, PhD, FCOphth;
Eberhart Zrenner, MD, PhD;
Gerard J. van Meel, MD, PhD;
Jan E. E. Keunen, MD, PhD;
Dirk van Norren, PhD
Arch Ophthalmol. 1991;109(8):1104-1108.
Abstract
• Four unrelated males with X-linked retinoschisis and a golden fundus reflex had Mizuo-Nakamura phenomenon, which, to our knowledge, has been described only in Oguchi's disease and X-linked cone dystrophy. These findings, together with experimental observations and data from the literature, led us to hypothesize that the Mizuo-Nakamura phenomenon is caused by an excess of extracellular potassium in the retina as a result of a decreased potassium scavenging capacity of retinal Müller cells.
Author Affiliations
From the Institute of Ophthalmology, the Erasmus University Rotterdam, the Netherlands (Dr de Jong); the Department of Ophthalmology, Eberhard-Karls University, Tübingen, Germany (Dr Zrenner); and the Department of Ophthalmology, the University of Utrecht, the Netherlands (Drs van Meel, Keunen, and van Norren).
Footnotes
Accepted for publication February 7, 1991.
Presented in part at the 183rd meeting of the Dutch Ophthalmological Society, Alkmaar, the Netherlands, March 15, 1989, and the 87th meeting of the German Ophthalmological Society, Heidelberg, Germany, September 24, 1989.
Reprint requests to the Institute of Ophthalmology, Erasmus University Rotterdam, PO Box 1738, 3000 DR Rotterdam, the Netherlands (Dr de Jong).
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