Mizuo phenomenon in X-linked retinoschisis. Pathogenesis of the Mizuo phenomenon

P. T. de Jong, E. Zrenner, G. J. van Meel, J. E. Keunen and D. van Norren
Institute of Ophthalmology, Erasmus University, Rotterdam, The Netherlands.

Four unrelated males with X-linked retinoschisis and a golden fundus reflex had Mizuo-Nakamura phenomenon, which, to our knowledge, has been described only in Oguchi's disease and X-linked cone dystrophy. These findings, together with experimental observations and data from the literature, led us to hypothesize that the Mizuo-Nakamura phenomenon is caused by an excess of extracellular potassium in the retina as a result of a decreased potassium scavenging capacity of retinal Muller cells.

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